Publication:
Cardiac troponin T: Its role in the diagnosis of clinically suspected acute myocarditis and chronic dilated cardiomyopathy in children

dc.contributor.authorJ. Soongswangen_US
dc.contributor.authorK. Durongpisitkulen_US
dc.contributor.authorS. Ratanarapeeen_US
dc.contributor.authorW. Leowattanaen_US
dc.contributor.authorA. Nanaen_US
dc.contributor.authorD. Laohaprasitipornen_US
dc.contributor.authorS. Akanirojen_US
dc.contributor.authorN. Limpimwongen_US
dc.contributor.authorC. Kangkagateen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-07-24T03:10:59Z
dc.date.available2018-07-24T03:10:59Z
dc.date.issued2002-01-01en_US
dc.description.abstractThis study was conducted to assess the use of the serum cardiac troponin T (cTnT) level as a noninvasive indicator to differentiate acute myocarditis and chronic dilated cardiomyopathy in pediatric patients. Myocarditis and dilated cardiomyopathy are clinically difficult to differentiate. Endomyocardial biopsy proved to be quite useful. However, the nature of the procedure - invasiveness, time-consuming, and limited sensitivity - caused some concerns, especially in pediatric patients. Hence, we attempted to find an alternative method that could give a prompt diagnosis of acute myocarditis. Twenty cases with clinically suspected myocarditis or dilated cardiomyopathy and a control group of 21 cases with moderate left-to-right shunt and congestive heart failure were recruited. History, physical examination, electrocardiogram, chest roentgenogram, echocardiogram, cTnT, creatine kinase MB isoenzyme (CK-MB mass), and/or endomyocardial biopsy were compared. The gold standard used to diagnose myocarditis is endomyocardial biopsy (Dallas criteria) and/or recovery from cardiovascular problems within 6 months of follow-up. Ten patients were diagnosed as having myocarditis (group 1) and 10 with chronic dilated cardiomyopathy (group 2). The control group of 21 cases was designated as group 3. The median serum cTnT levels were 0.088 (0.04-3.11), 0.010 (0.010-0.990), and 0.010 (0.010-0.550) ng/ml in groups 1, 2, and 3, respectively. The mean CK-MB mass level for groups, 1, 2, and 3 were 18.35 (7.14-70.00), 4.80 (0.54-108.00), and 2.26 (0.95-7.06) ng/ml. The study showed that both the cTnT and CK-MB mass levels were significantly higher in group 1 than either group 2 or group 3. Histopathology was studied in 9 cases. In 2 of 5 cases and in all 4 cases in group 1 and group 2 histopathology was pathologically proved. Levels of cTnT and CK-MB were significantly higher for myocarditis than for dilated cardiomyopathy and left-to-right shunt with CHF. Further study is needed to assess the optimum cTnT level for differentiating both conditions.en_US
dc.identifier.citationPediatric Cardiology. Vol.23, No.5 (2002), 531-535en_US
dc.identifier.doi10.1007/PL00021005en_US
dc.identifier.issn01720643en_US
dc.identifier.other2-s2.0-85047688330en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/20578
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85047688330&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleCardiac troponin T: Its role in the diagnosis of clinically suspected acute myocarditis and chronic dilated cardiomyopathy in childrenen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85047688330&origin=inwarden_US

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