Publication: Treatment of malaria: Some considerations and limitations of the current methods of assessment
Issued Date
1989-01-01
Resource Type
ISSN
18783503
00359203
00359203
Other identifier(s)
2-s2.0-0024355938
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.83, No.6 (1989), 767-777
Suggested Citation
N. J. White, S. Krishna Treatment of malaria: Some considerations and limitations of the current methods of assessment. Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.83, No.6 (1989), 767-777. doi:10.1016/0035-9203(89)90322-2 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15774
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Title
Treatment of malaria: Some considerations and limitations of the current methods of assessment
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Abstract
The currently used methods for assessing the therapeutic response to antimalarial drugs are relatively imprecise and insensitive. These methods are inadequate in severe malaria when the objectives of treatment are to save life and prevent complications. Very large studies are needed to demonstrate significant differences in mortality, but measurement of the rates of clinical, biochemical, and parasitological response may provide useful comparative information. Definitions, assessment criteria, procedures, and data collection forms should be standardized and evaluated prospectively. Antimalarial drug treatment in different clinical situations should be assessed in terms of the balance between the risks of drug toxicity and the benefits of the antimalarial drug action. This balance is considerably different in severe falciparum malaria compared with uncomplicated malaria infections. © 1989 Oxford University Press.