Publication: Spleen in falciparum malaria: ultrastructural study.
Issued Date
1987-12-01
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ISSN
01251562
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2-s2.0-0023514089
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Mahidol University
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SCOPUS
Bibliographic Citation
The Southeast Asian journal of tropical medicine and public health. Vol.18, No.4 (1987), 491-501
Suggested Citation
E. Pongponratn, M. Riganti, D. Bunnag, T. Harinasuta Spleen in falciparum malaria: ultrastructural study.. The Southeast Asian journal of tropical medicine and public health. Vol.18, No.4 (1987), 491-501. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15379
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Title
Spleen in falciparum malaria: ultrastructural study.
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Abstract
An ultrastructural study was undertaken of the spleen of 13 year-old-boy who died of falciparum malaria. The spleen revealed the following: both parasitized and non-parasitized erythrocytes are phagocytosed in large numbers by macrophages, littoral and reticular cells. Blood congestion and trapping of parasitized erythrocytes are commonly seen in splenic sinusoids and cords. Erythrocytes forming rosette structure around immuno-presenting cells is observed. The results of this study provide evidence that the mechanisms underlying splenic host defence in malaria include both immunological and non-immunological interaction with erythrocytes. Splenic trapping of parasitized erythrocytes is an important defence mechanism and the phagocytosis of erythrocytes probably accounts for anaemia.