Publication: Neuroprotective effect of metformin on dopaminergic neurodegeneration and α-synuclein aggregation in C. elegans model of Parkinson's disease
Issued Date
2021-01-01
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ISSN
18728111
01680102
01680102
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2-s2.0-85077007923
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Mahidol University
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SCOPUS
Bibliographic Citation
Neuroscience Research. Vol.162, (2021), 13-21
Suggested Citation
Nada Saewanee, Theethawat Praputpittaya, Nawaphat Malaiwong, Pawanrat Chalorak, Krai Meemon Neuroprotective effect of metformin on dopaminergic neurodegeneration and α-synuclein aggregation in C. elegans model of Parkinson's disease. Neuroscience Research. Vol.162, (2021), 13-21. doi:10.1016/j.neures.2019.12.017 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/78904
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Title
Neuroprotective effect of metformin on dopaminergic neurodegeneration and α-synuclein aggregation in C. elegans model of Parkinson's disease
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Abstract
• Parkinson's disease (PD), the second most progressive neurodegenerative disease causing motor impairment and defective cognitive function, has been a burden to the quality of life for decades and remain incurable. Metformin, a biguanide anti-diabetic drugs for type 2 diabetes mellitus, recently exhibits a neuroprotective effect in many neurological disorders. Ultimately, the aim of the study was to elucidate the neuroprotective effects of metformin against PD in C. elegans models of 6-hydroxydopamine-induced dopaminergic neurodegeneration and α-synuclein protein aggregation. Our experiments showed that 10 mM metformin significantly decreased neurodegeneration in 6-hydroxydopamine-induced worms, and recovered its food-sensing behavior without an affect to the nematode development. Moreover, 10 mM metformin also inhibited α-synuclein aggregation and recovered the lipid deposition. Gene expression analysis revealed that metformin could upregulate cat-2 gene expression and GFP-tagged SOD-3 expression. However, metformin did not significantly alter mean or maximum lifespan of the PD model organism. Therefore, this study highlighted the neuroprotective effects of metformin on dopaminergic neurons and α-synuclein, while its precise mechanism should be conducted in the future.