Publication: Quantitation of Cell-Derived Microparticles in Blood Products and Its Potential Applications in Transfusion Laboratories
Issued Date
2020-09-01
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ISSN
19437730
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2-s2.0-85090172641
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Mahidol University
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SCOPUS
Bibliographic Citation
Laboratory medicine. Vol.51, No.5 (2020), 452-459
Suggested Citation
Egarit Noulsri Quantitation of Cell-Derived Microparticles in Blood Products and Its Potential Applications in Transfusion Laboratories. Laboratory medicine. Vol.51, No.5 (2020), 452-459. doi:10.1093/labmed/lmz100 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/58961
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Title
Quantitation of Cell-Derived Microparticles in Blood Products and Its Potential Applications in Transfusion Laboratories
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Abstract
© American Society for Clinical Pathology 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. Cell-derived microparticles (MPs) are small fragments released from various cells when they are activated or undergo apoptosis. In the field of transfusion medicine, a number of studies have documented increased levels of MPs in blood products, which have been associated with multiple factors, including donor variability, blood component processing, and storage. In addition, transfusions that contain high levels of MPs are linked to posttransfusion complications. Considering the clinical importance of MP levels, transfusion laboratories should routinely screen blood products for them. However, this practice is not yet applied routinely, perhaps in part because of a lack of understanding of how to apply MP data to transfusion medicine. We describe the methods used to quantitate MPs in blood components and discuss the application of these quantitative data in routine transfusion laboratories in order to manage quality, improve the outcomes of transfusions, and minimize their complications.