Publication:
Expansion of inefficient HIV-specific CD8 T cells during acute infection

Issued Date

2016-04-01

Resource Type

Article

ISSN

10985514
0022538X

DOI

10.1128/JVI.02785-15

Other identifier(s)

2-s2.0-84963864427

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Journal of Virology. Vol.90, No.8 (2016), 4005-4016

Suggested Citation

Michael A. Eller, Nilu Goonetilleke, Boonrat Tassaneetrithep, Leigh Anne Eller, Margaret C. Costanzo, Susan Johnson, Michael R. Betts, Shelly J. Krebs, Bonnie M. Slike, Sorachai Nitayaphan, Kathleen Rono, Sodsai Tovanabutra, Lucas Maganga, Hannah Kibuuka, Linda Jagodzinski, Sheila Peel, Morgane Rolland, Mary A. Marovich, Jerome H. Kim, Nelson L. Michael, Merlin L. Robb, Hendrik Streeck Expansion of inefficient HIV-specific CD8 T cells during acute infection. Journal of Virology. Vol.90, No.8 (2016), 4005-4016. doi:10.1128/JVI.02785-15 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/41314

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Title

Expansion of inefficient HIV-specific CD8 T cells during acute infection

Author(s)

Michael A. Eller
 Nilu Goonetilleke
 Boonrat Tassaneetrithep
 Leigh Anne Eller
 Margaret C. Costanzo
 Susan Johnson
 Michael R. Betts
 Shelly J. Krebs
 Bonnie M. Slike
 Sorachai Nitayaphan
 Kathleen Rono
 Sodsai Tovanabutra
 Lucas Maganga
 Hannah Kibuuka
 Linda Jagodzinski
 Sheila Peel
 Morgane Rolland
 Mary A. Marovich
 Jerome H. Kim
 Nelson L. Michael
 Merlin L. Robb
 Hendrik Streeck

Other Contributor(s)

Walter Reed Army Institute of Research
 HJF
 The University of North Carolina at Chapel Hill
 Mahidol University
 University of Pennsylvania
 Armed Forces Research Institute of Medical Sciences, Thailand
 Walter Reed Project-Kenya
 Walter Reed Program-Tanzania
 Makerere University
 Universitats Klinikum Essen und Medizinische Fakultat
 International Vaccine Institute, Seoul
 National Institute of Allergy and Infectious Diseases

Abstract

© 2016, American Society for Microbiology. Attrition within the CD4+T cell compartment, high viremia, and a cytokine storm characterize the early days after HIV infection. When the first emerging HIV-specific CD8+T cell responses gain control over viral replication it is incomplete, and clearance of HIV infection is not achieved even in the rare cases of individuals who spontaneously control viral replication to nearly immeasurably low levels. Thus, despite their partial ability to control viremia, HIV-specific CD8+T cell responses are insufficient to clear HIV infection. Studying individuals in the first few days of acute HIV infection, we detected the emergence of a unique population of CD38+CD27-CD8+T cells characterized by the low expression of the CD8 receptor (CD8dim). Interestingly, while high frequencies of HIV-specific CD8+T cell responses occur within the CD38+CD27-CD8dimT cell population, the minority populations of CD8brightT cells are significantly more effective in inhibiting HIV replication. Furthermore, the frequency of CD8dimT cells directly correlates with viral load and clinical predictors of more rapid disease progression. We found that a canonical burst of proliferative cytokines coincides with the emergence of CD8dimT cells, and the size of this population inversely correlates with the acute loss of CD4+T cells. These data indicate, for the first time, that early CD4+T cell loss coincides with the expansion of a functionally impaired HIV-specific CD8dimT cell population less efficient in controlling HIV viremia.

Keyword(s)

Agricultural and Biological Sciences
 Immunology and Microbiology

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/41314

Collections

Scopus 2016-2017