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Insulin does not rescue cortical and trabecular bone loss in type 2 diabetic Goto-Kakizaki rats

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dc.contributor.authorRatchaneevan Aeimlapaen_US
dc.contributor.authorNarattaphol Charoenphandhuen_US
dc.contributor.authorPanan Suntornsaratoonen_US
dc.contributor.authorKannikar Wongdeeen_US
dc.contributor.authorWacharaporn Tiyasatkulkoviten_US
dc.contributor.authorKanchana Kengkoomen_US
dc.contributor.authorNateetip Krishnamraen_US
dc.contributor.otherChulalongkorn Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherBurapha Universityen_US
dc.date.accessioned2019-08-23T10:28:29Z
dc.date.available2019-08-23T10:28:29Z
dc.date.issued2018-09-01en_US
dc.description.abstract© 2017, The Physiological Society of Japan and Springer Japan KK. In type 2 diabetes mellitus (T2DM), the decreased bone strength is often associated with hyperglycemia and bone cell insulin resistance. Since T2DM is increasingly reported in young adults, it is not known whether the effect of T2DM on bone would be different in young adolescents and aging adults. Here, we found shorter femoral and tibial lengths in 7-month, but not 13-month, Goto-Kakizaki (GK) T2DM rats as compared to wild-type rats. Bone µCT analysis showed long-lasting impairment of both cortical and trabecular bones in GK rats. Although insulin treatment effectively improved hyperglycemia, it was not able to rescue trabecular BMD and cortical thickness in young adult GK rats. In conclusion, insulin treatment and alleviation of hyperglycemia did not increase BMD of osteopenic GK rats. It is likely that early prevention of insulin resistance should prevail over treatment of full-blown T2DM-related osteopathy.en_US
dc.identifier.citationJournal of Physiological Sciences. Vol.68, No.5 (2018), 531-540en_US
dc.identifier.doi10.1007/s12576-017-0558-4en_US
dc.identifier.issn18806546en_US
dc.identifier.other2-s2.0-85022071002en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/45059
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85022071002&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleInsulin does not rescue cortical and trabecular bone loss in type 2 diabetic Goto-Kakizaki ratsen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85022071002&origin=inwarden_US

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