Publication: Effects of cytochalasin E on H+ and volume secretion in gastric fistula rats
| dc.contributor.author | Thirayudh Glinsukon | en_US |
| dc.contributor.author | Wisuda Suvitayawat | en_US |
| dc.contributor.author | Somphong Sahaphong | en_US |
| dc.contributor.author | Pawinee Piyachaturawat | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.date.accessioned | 2018-06-14T09:05:27Z | |
| dc.date.available | 2018-06-14T09:05:27Z | |
| dc.date.issued | 1987-01-01 | en_US |
| dc.description.abstract | Effects of cytochalasin E on the secretion of H + and volume of gastric juice were investigated in gastric fistula rats. Direct exposure of the gastric mucosa to cytochalasin E (5-20 μg/ml) inhibited H + secretory rate in all of the pentagastrin-, histamine- as well as non-stimulated rats but it did not affect the secretory volume of gastric juice. The inhibitory action of cytochalasin E on H + secretion had a rapid onset and showed a dose-dependent pattern. The mechanism of inhibitory action was not related to its interaction with plasma membrane receptors or membrane enzyme, K + -stimulated ATPase. Interference with cellular energy production as well as alteration of microfilament function, which are essential for H + production and secretion respectively, are likely to be the bases of the cytochalasin inhibition. © 1987. | en_US |
| dc.identifier.citation | Toxicology Letters. Vol.36, No.1 (1987), 95-103 | en_US |
| dc.identifier.doi | 10.1016/0378-4274(87)90046-4 | en_US |
| dc.identifier.issn | 03784274 | en_US |
| dc.identifier.other | 2-s2.0-0023132872 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/15473 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0023132872&origin=inward | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | Effects of cytochalasin E on H+ and volume secretion in gastric fistula rats | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0023132872&origin=inward | en_US |
