Publication:
Interleukin-1β level in gingival crevicular fluid of patients with active periodontitis

dc.contributor.authorP. Suwatanapongcheden_US
dc.contributor.authorP. Laohapanden_US
dc.contributor.authorR. Surariten_US
dc.contributor.authorY. Ohmotoen_US
dc.contributor.authorK. Ruxrungthamen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-09-07T09:11:12Z
dc.date.available2018-09-07T09:11:12Z
dc.date.issued2000-12-01en_US
dc.description.abstractPrevious studies revealed that interleukin-1beta (IL-1β) was detectable in gingival crevicular fluid (GCF) of patients with periodontitis, and the level was increased in level in gingival tissue extracts of active periodontal disease sites (defined as attachment loss ≥ 2.5 mm over the preceding 2 months) compared to inactive sites or healthy sites. The present study evaluated the relationship of IL-1β level in GCF and periodontal disease status. GCF was collected with Periopaper strips from 34 disease-active and 45 disease-inactive teeth in 11 untreated periodontitis patients and from 60 teeth in 15 healthy control subjects. Disease activity was defined as attachment loss of ≥ 2.5 mm in at least one site of a tooth as determined by sequential probing. The absorbed GCF volume was determined using a Periotron 6000 and the crevicular IL-1β level was determined using IL-1β monoclonal antibody (Otsuka Pharmaceutical, Japan). IL-1β was below the detection level of the assay (6 pg/ml) in the healthy control group but was detected in most teeth of the periodontitis group. However, disease-active teeth had higher IL-1β level (Mann-Whitney U-test, p < 0.05) than disease-inactive teeth (mean total IL-1β of 5.89 ± 7.88 pg/tooth and 1.72 ± 2.28 pg/tooth; mean concentration of 1.6 ± 2.5 ng/ml and 0.6 ± 0.83 ng/ml, respectively). The level of IL-1β showed no correlation with probing depth, but had significant correlation (p < 0.05) with the extent of attachment loss. This study suggests that the level of IL-1β in GCF may have a predictive value for determining active and inactive periodontal status.en_US
dc.identifier.citationAsian Pacific Journal of Allergy and Immunology. Vol.18, No.4 (2000), 201-207en_US
dc.identifier.issn0125877Xen_US
dc.identifier.other2-s2.0-0034351485en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/25953
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0034351485&origin=inwarden_US
dc.subjectImmunology and Microbiologyen_US
dc.subjectMedicineen_US
dc.titleInterleukin-1β level in gingival crevicular fluid of patients with active periodontitisen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0034351485&origin=inwarden_US

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