Subtype-specific transmission probabilities for human immunodeficiency virus type 1 among injecting drug users in Bangkok, Thailand

dc.contributor.authorMichael G. Hudgensen_US
dc.contributor.authorIra M. Longinien_US
dc.contributor.authorSuphak Vanichsenien_US
dc.contributor.authorDale J. Huen_US
dc.contributor.authorDwip Kitayapornen_US
dc.contributor.authorPhilip A. Mocken_US
dc.contributor.authorM. Elizabeth Halloranen_US
dc.contributor.authorGlen A. Sattenen_US
dc.contributor.authorKachit Choopanyaen_US
dc.contributor.authorTimothy D. Mastroen_US
dc.contributor.otherRollins School of Public Healthen_US
dc.contributor.otherFred Hutchinson Cancer Research Centeren_US
dc.contributor.otherBangkok Metropolitan Administrationen_US
dc.contributor.otherNational Center for HIV/AIDS, Viral Hepatitis, STD, and TB Preventionen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherHIV/AIDS Collaborationen_US
dc.description.abstractThe Bangkok (Thailand) Metropolitan Administration cohort of injecting drug users (IDUs) consisted of 1,209 IDUs initially seronegative for human immunodeficiency virus (HIV) who were followed from 1995 to 1998 at 15 Administration drug treatment clinics. At enrollment and approximately every 4 months thereafter, participants were assessed for HIV seropositivity. As of December 1998, there were 133 HIV type 1 seroconversions and approximately 2,300 person-years of follow-up. Of the 133 observed seroconversions, specimens from 126 persons were available for subtyping (27 subtype B, 99 subtype E). In this analysis, the authors assessed differences in subtype-specific transmission while controlling for important risk factors. The methodology used accounts for left truncation, interval censoring, and competing risks as well as for time-varying covariates such as each IDU's history of reported frequency of injection and of incarceration. Using plausible epidemiologic assumptions and controlling for behavioral risks, the authors found that a significantly higher transmission probability was associated with subtype E compared with subtype B in this population. Since many epidemiologic, virologic, and host factors can influence HIV transmission, it was difficult to conclude whether these differences in transmission probabilities were due to biologic properties associated with subtype.en_US
dc.identifier.citationAmerican Journal of Epidemiology. Vol.155, No.2 (2002), 159-168en_US
dc.rightsMahidol Universityen_US
dc.titleSubtype-specific transmission probabilities for human immunodeficiency virus type 1 among injecting drug users in Bangkok, Thailanden_US