Publication: Combined hepatocellular and cholangiocarcinoma with sarcomatous transformation
Issued Date
2007-03-01
Resource Type
ISSN
01252208
01252208
01252208
Other identifier(s)
2-s2.0-33947272008
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.90, No.3 (2007), 574-580
Suggested Citation
Paisarn Boonsakan, Orathai Thangnapakorn, Jiemjit Tapaneeyakorn, Sawit Kositchaiwat, Sukhum Bunyaratvej Combined hepatocellular and cholangiocarcinoma with sarcomatous transformation. Journal of the Medical Association of Thailand. Vol.90, No.3 (2007), 574-580. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/24963
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Combined hepatocellular and cholangiocarcinoma with sarcomatous transformation
Other Contributor(s)
Abstract
Combined hepatocellular and cholangiocarcinoma with sarcomatous transformation was first recognized in Ramathibodi Hospital in 2005. This variant of carcinoma has been increasingly reported particularly from Asian countries. Dedifferentiation of the epithelial component to various sarcomatous components is likely the underlying mechanism. The causative factors of hepatocarcinogenesis in Thailand include chronic viral hepatitis B or C, exposures to aflatoxin B1 and nitrosamine(s) and occasionally some certain nodular hepatocellular lesions due to arterial hyperperfusion. It is suggested that the recent change of the Thai peoples' life style to an increased consumption of fast foods containing food preservatives especially nitrate or nitrite, the nitrosamine precursor, may allow heavy exposure(s) to the chemical carcinogen(s) i.e. nitrosamine(s) leading to sarcomatous transformation of the carcinoma.