Publication: A histopathological study of hearts and spleens of hamsters (Mesocricetus auratus) infected with Leptospira interrogans, serovar pyrogenes
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Issued Date
2006-07-01
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01251562
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2-s2.0-33750206327
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Mahidol University
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SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.37, No.4 (2006), 720-728
Suggested Citation
Jittima Muensoongnoen, Duangporn Phulsuksombati, Paisal Parichatikanond, Noppadon Sangjan, Chaiyaphruk Pilakasiri, Kesorn Sripaoraya, Jantima Roongruangchai, Kasem Koedpuech, Kajee Pilakasiri A histopathological study of hearts and spleens of hamsters (Mesocricetus auratus) infected with Leptospira interrogans, serovar pyrogenes. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.37, No.4 (2006), 720-728. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/23710
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Title
A histopathological study of hearts and spleens of hamsters (Mesocricetus auratus) infected with Leptospira interrogans, serovar pyrogenes
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Abstract
The effects of Leptospira interrogans on the heart and spleen of hamsters were studied histopathologically. Infected hamsters were sacrificed at 1 hour, 6 hours and on days 1, 2, 3, 4, 5 and 6 after inoculation with Leptospira interrogans serovar pyrogenes. The heart and spleen of each of the sacrificed animals were removed and processed for routine conventional light microscopy. Infected hearts showed degenerative change of the cardiac muscle cells composed of cellular swelling, condensation of chromatin granules, pyknotic nuclei and acidophilic cytoplasm. Congestion of the cardiac blood vessels and hemorrhagic areas were found. Necrosis of the cardiac muscle cells was surrounded by numerous inflammatory cells. In the spleen, cellular necrosis was found scattered throughout the splenic cord. The splenic sinusoids were dilated and congested with many hemorrhagic areas. Inflammatory cell infiltration was also noted in the splenic parenchyma and the splenic sinusoids.