Publication: Ethnic differences in the renal sodium-dopamine relationship: a possible explanation for regional variation in the prevalence of hypertension?
Issued Date
1989-11-01
Resource Type
ISSN
14321041
00316970
00316970
Other identifier(s)
2-s2.0-0024803464
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
European Journal of Clinical Pharmacology. Vol.37, No.6 (1989), 559-562
Suggested Citation
J. A.J.H. Critchley, M. R. Lee, C. J. Gordon, K. Makarananda, K. Sriwatanakul, M. Balali-Mood, G. L. Boye Ethnic differences in the renal sodium-dopamine relationship: a possible explanation for regional variation in the prevalence of hypertension?. European Journal of Clinical Pharmacology. Vol.37, No.6 (1989), 559-562. doi:10.1007/BF00562544 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15794
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Title
Ethnic differences in the renal sodium-dopamine relationship: a possible explanation for regional variation in the prevalence of hypertension?
Abstract
Twenty-four-h urinary sodium and dopamine output by normotensive adults from 5 different ethnic groups have been measured. The groups differed substantially in the correlation between the urinary output ot sodium and dopamine. Those with a traditionally salt rich diet (Thais, Caucasians, Zimbabweans) showed a strong positive correlation (p < 0.001), whereas no such relationship was found in West Africans and Iranians, who come from traditionally salt scarce environments. It is hypothesised that in some races the lack of or uncoupling of the renal sodium-dopamine relationship, possibly as a mechanism to help conserve dietary sodium, predisposes to the development of hypertension when the individuals encounter a salt rich diet. © 1989 Springer-Verlag.