Publication: SLC35B2 expression is associated with a poor prognosis of invasive ductal breast carcinoma
Issued Date
2014-01-01
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ISSN
15137368
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2-s2.0-84906271223
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Mahidol University
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SCOPUS
Bibliographic Citation
Asian Pacific Journal of Cancer Prevention. Vol.15, No.15 (2014), 6065-6070
Suggested Citation
Anongruk Chim-Ong, Charin Thawornkuno, Porntip Chavalitshewinkoon-Petmitr, Phaibul Punyarit, Songsak Petmitr SLC35B2 expression is associated with a poor prognosis of invasive ductal breast carcinoma. Asian Pacific Journal of Cancer Prevention. Vol.15, No.15 (2014), 6065-6070. doi:10.7314/APJCP.2014.15.15.6065 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/33377
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Title
SLC35B2 expression is associated with a poor prognosis of invasive ductal breast carcinoma
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Abstract
Background: Breast cancer is the most common malignancy in women worldwide, including Thailand, and is a major cause of mortality and morbidity, despite advances in diagnosis and treatment. Novel gene expression in breast cancer is a focus in searches for prognostic biomarkers and new therapeutic targets. Materials and Methods: The mRNA expression of novel B4GALT4, SLC35B2, and WDHD1 genes in breast cancer were examined in invasive ductal breast carcinoma (IDC) patients using quantitative real-time reverse transcription polymerase chain reaction (QRT-PCR). Results: Among these genes, increased expression of SLC35B2 mRNA was significantly associated with TNM stage III + IV of IDC (p < 0.001). Hence, up-regulation of SLC35B2 may serve as a prognostic biomarker for poor prognosis, and is also a potential therapeutic target in breast cancer.