Publication: Performance of Siriraj liquid-based cytology: A single center report concerning over 100,000 samples
Issued Date
2014-01-01
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ISSN
2476762X
15137368
15137368
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2-s2.0-84899092886
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Mahidol University
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SCOPUS
Bibliographic Citation
Asian Pacific Journal of Cancer Prevention. Vol.15, No.5 (2014), 2051-2055
Suggested Citation
Suthi Sangkarat, Somsak Laiwejpithaya, Manee Rattanachaiyanont, Pattama Chaopotong, Mongkol Benjapibal, Weerasak Wongtiraporn, Sujera Laiwejpithaya Performance of Siriraj liquid-based cytology: A single center report concerning over 100,000 samples. Asian Pacific Journal of Cancer Prevention. Vol.15, No.5 (2014), 2051-2055. doi:10.7314/APJCP.2014.15.5.2051 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/33372
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Title
Performance of Siriraj liquid-based cytology: A single center report concerning over 100,000 samples
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Abstract
To evaluate the performance of Siriraj liquid-based cytology (LBC) for cervical neoplasia screening after increasing use of this technology. Materials and Methods: Cytological reports of 103,057 Siriraj-LBC specimens obtained in 2007-2009 were compared with those of 23,676 specimens obtained in 2006. Results: Comparing with the year 2006, the 2007-2009 patients were slightly older (43.4±12.yr vs 42.7±12.2 yr, p <0.001), and their specimens had much lower proportion of unsatisfactory slides (OR=0.06, 95%CI 0.04-0.09) with comparable detection rates (3.96% vs 3.70%, p=0.052) but different proportions of various cytological abnormalities (p<0.001). The 2007-2009 Siriraj-LBC had a negative predictive value (NPV) for cervical intraepithelial neoplasia 2+ (CIN2+) of 97.6% and an overall positive predictive value (PPV) of 43.9%. The PPV for CIN2+ varied with types of abnormal cytology, from 13.7% to 93.8% in atypical squamous cells of undetermined significance (ASCUS), low-grade squamous intraepithelial lesion (LSIL), atypical squamous cells cannot exclude HSIL (ASC-H), high-grade squamous intraepithelial lesion (HSIL), atypical glandular cells (AGC), to squamous cell carcinoma (SCC), respectively. The PPVs for CIN2+ in ASCUS and LSIL were comparable, but the PPV for CIN1 was higher for LSIL than for ASCUS (41.63% vs 16.32%). Conclusions: Siriraj-LBC has demonstrated a stable detection rate and NPV for CIN2+ of >95% since the first year of use. The comparable PPVs for CIN2+ of ASCUS and LSIL suggests that these two conditions may undergo similar management; other cytological abnormalities need immediate evaluation.