Publication: Effect of chronic K<sup>+</sup> deficiency on contractile properties of soleus muscle in rats: Evidence of sex differences
Issued Date
1999-04-26
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03051870
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2-s2.0-0032945463
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Mahidol University
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SCOPUS
Bibliographic Citation
Clinical and Experimental Pharmacology and Physiology. Vol.26, No.4 (1999), 323-329
Suggested Citation
Pawinee Piyachaturawat, Suparporn Muchimapura, Samaisukh Sophasan, Surawat Jariyawat, Chumpol Pholpramool, Jutamaad Satayavivad, Hitoshi Endou Effect of chronic K<sup>+</sup> deficiency on contractile properties of soleus muscle in rats: Evidence of sex differences. Clinical and Experimental Pharmacology and Physiology. Vol.26, No.4 (1999), 323-329. doi:10.1046/j.1440-1681.1999.03036.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/25344
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Title
Effect of chronic K<sup>+</sup> deficiency on contractile properties of soleus muscle in rats: Evidence of sex differences
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Abstract
1. Alterations in skeletal muscle function of chronically K+-depleted male and female rats were investigated in isolated soleus muscles. 2. By 16 weeks K+ deficiency, plasma K+ concentrations in both male and female rats were reduced to approximately 2 mEq/L, which was accompanied by an approximate 50% reduction in muscle K+ content and a marked increase in muscle Na+ content. These changes were similar in both males and females. 3. Plasma creatine phosphokinase activity progressively increased with time in K+-depleted male rats, whereas only a slight increase was observed in female rats. 4. Maximum isometric twitch tension (Pt) and tetanic tension (Po) of K+-depleted soleus muscles from male rats was markedly suppressed; this was not seen for soleus muscles obtained from female rats. 5. After exposure to insulin in low-K+ solution, the contractile tension of soleus from the K+- depleted male rats was suppressed to a greater extent. 6. All alterations in muscle function during chronic K+ depletion were restored to normal after 2 weeks K+ repletion. 7. The results suggest that there is a preponderance for male over female rats in developing alterations in skeletal muscle function during chronic K+ deficiency. The changes may be associated with abnormalities of muscle membrane permeability and cellular function.