Publication: Brain MRI study in thai patient with neuromyelitis optica
Issued Date
2018-01-01
Resource Type
ISSN
01252208
Other identifier(s)
2-s2.0-85042357791
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.101, No.1 (2018), 126-130
Suggested Citation
Pattaranun Sangwirotekun, Oranan Tritanon, Panitha Jindahra, Teeratorn Pulkes, Disya Ratanakorn, Pairoj Boonkongchuen, Charungthai Dejthevaporn, Jesada Keandoungchun, Pisit Preechawat, Anuchit Poonyathalung, Metha Apiwattanakul, Jiraporn Laothamatas, Supoch Tunlayadechanont Brain MRI study in thai patient with neuromyelitis optica. Journal of the Medical Association of Thailand. Vol.101, No.1 (2018), 126-130. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/47153
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Brain MRI study in thai patient with neuromyelitis optica
Abstract
© 2018, Medical Association of Thailand. All rights reserved. Background: Neuromyelitis optica spectrum disease [NMOSD] is an inflammatory disease of the central nervous system involving optic nerve, spinal cord, and brain. Asymptomatic brain abnormalities were recorded in some countries but the data in Thailand were limited. Objective: To evaluate asymptomatic NMOSD brain abnormalities and their relation to clinical relapses in Thai patients. Materials and Methods: This was a retrospective study, recruiting 27 NMOSD patients in a tertiary care center in Thailand. All patients were seropositive for aquaporin-4 IgG. Magnetic resonance imaging [MRI] of the brain was performed in every case. Results: Twenty-four cases (88.89%) had asymptomatic hyperintensities on fluid-attenuated inversion recovery images [FLAIR]. These lesions were widespread across the brain even in areas with low density of aquaporin-4. To our knowledge, a fornix lesion was reported for the first time in a patient with acute optic neuritis. By using linear regression analysis, no significant correlation between annual relapse rate [ARR] and the number of asymptomatic FLAIR hyperintensities was established (coefficient 0.02, 95% confidence interval -0.0009 to 0.04, p = 0.06). Conclusion: Asymptomatic FLAIR hyperintensities on brain MRIs are frequently found in NMOSD. They may not correlate with clinical relapses. Further cohort studies are required. To our knowledge, this is the first report of a fornix lesion in a NMOSD patient presented with acute optic neuritis.