Publication: Anticancer activities of antimicrobial BmKn2 peptides against oral and colon cancer cells
Issued Date
2014-01-01
Resource Type
ISSN
15733904
15733149
15733149
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2-s2.0-84939890005
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Peptide Research and Therapeutics. Vol.20, No.4 (2014), 501-509
Suggested Citation
Teerakul Arpornsuwan, Wimolpak Sriwai, Janthima Jaresitthikunchai, Narumon Phaonakrop, Hathaitip Sritanaudomchai, Sittiruk Roytrakul Anticancer activities of antimicrobial BmKn2 peptides against oral and colon cancer cells. International Journal of Peptide Research and Therapeutics. Vol.20, No.4 (2014), 501-509. doi:10.1007/s10989-014-9417-9 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/33467
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Title
Anticancer activities of antimicrobial BmKn2 peptides against oral and colon cancer cells
Abstract
© 2014 Springer Science+Business Media New York. There is considerable current interest in developing antimicrobial and anticancer agents with a new mode of action. The antimicrobial peptides are regarded as a potential solution for treating cancer cells. The antimicrobial effect of 6 synthetic peptides against 7 bacterial species was evaluated. The result showed that IsCT, BmKn2 and BMAP-28 exhibited broad range of action against Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 6538, methicillin resistant S. aureus DMST 20651, Staphylococcus epidermidis ATCC 12228, Acinetobacter baumanii ATCC 19066, Escherichia coli ATCC 25922 and Salmonella typhi DMST 562 at minimal inhibitory concentrations (MIC) of 2.97-24.28 μM. Neither AMP induced significant hemolysis, or showed cytotoxic on dental pulp stem cells and smooth muscle cells at their MICs. In addition, BmKn2 inhibited growth of human oral squamous carcinoma HSC4 cells and human colon cancer SW620 cells with IC<inf>50</inf> of 17.26 and 40 μM, respectively. Taken together, BmKn2 peptide from scorpion venom may offer a novel therapeutic strategy for development of cationic antimicrobial and anticancer peptides as potential new therapeutic agents.