Publication: Atopic Disease and Herpes Simplex Eye Disease: A Population-Based Case-Control Study
Issued Date
2006-11-01
Resource Type
ISSN
00029394
Other identifier(s)
2-s2.0-33750049019
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
American Journal of Ophthalmology. Vol.142, No.5 (2006)
Suggested Citation
Tisha Prabriputaloong, Todd P. Margolis, Thomas M. Lietman, Ira G. Wong, Rookaya Mather, David C. Gritz Atopic Disease and Herpes Simplex Eye Disease: A Population-Based Case-Control Study. American Journal of Ophthalmology. Vol.142, No.5 (2006). doi:10.1016/j.ajo.2006.06.050 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23524
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Atopic Disease and Herpes Simplex Eye Disease: A Population-Based Case-Control Study
Abstract
Purpose: To determine whether atopy is associated with herpes simplex virus (HSV) ocular disease. Design: Retrospective, population-based, case-control study. Methods: setting: Large, regional health maintenance organization (Northern California Kaiser Permanente). study Population: 1,042,351 people over a one-year period. observation Procedures: Electronic database search for HSV ocular disease and subsequent chart review determined study eligibility. Two age-matched control groups (one population-based and one clinic-based) were randomly chosen. Medical record review determined the presence of atopy. Severe atopic disease was defined by diagnostic code or illness requiring an emergency room visit, hospitalization, or treatment with a systemic corticosteroid. main Outcome Measures: Presence of HSV eye disease, presence of atopy, and characterization of atopy severity. Results: HSV eye disease was found in 172 patients. HSV cases had a greater prevalence of atopy (34%, 58/172) than the clinic-based (25%, 43/172) or the population-based controls (21%, 36/172, odds ratio (OR) 1.5, 95% confidence interval (CI) 0.9 to 2.6 and OR 1.9, 95%, CI 1.1 to 3.3, respectively). The association of HSV ocular disease with severe atopy was even greater, with a history of severe atopic disease in 13% (22/172) of patients with HSV ocular disease as compared with 6% (11/172) of patients in the clinic control group and 3% (5/172) of patients in the population control group (OR 2.0, 95% CI 0.7 to 5.9 and OR 4.8, 95% CI 1.6 to 19.2, respectively). Conclusions: Patients with HSV ocular disease are more likely to have a history of atopic disease, especially severe atopic disease, than age-matched controls. © 2006 Elsevier Inc. All rights reserved.