Publication: Lung γδ T Cells Mediate Protective Responses during Neonatal Influenza Infection that Are Associated with Type 2 Immunity
Issued Date
2018-09-18
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ISSN
10974180
10747613
10747613
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2-s2.0-85055586852
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Mahidol University
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SCOPUS
Bibliographic Citation
Immunity. Vol.49, No.3 (2018), 531-544.e6
Suggested Citation
Xi zhi J. Guo, Pradyot Dash, Jeremy Chase Crawford, E. Kaitlynn Allen, Anthony E. Zamora, David F. Boyd, Susu Duan, Resha Bajracharya, Walid A. Awad, Nopporn Apiwattanakul, Peter Vogel, Thirumala Devi Kanneganti, Paul G. Thomas Lung γδ T Cells Mediate Protective Responses during Neonatal Influenza Infection that Are Associated with Type 2 Immunity. Immunity. Vol.49, No.3 (2018), 531-544.e6. doi:10.1016/j.immuni.2018.07.011 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/45963
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Title
Lung γδ T Cells Mediate Protective Responses during Neonatal Influenza Infection that Are Associated with Type 2 Immunity
Abstract
© 2018 Elsevier Inc. Compared to adults, infants suffer higher rates of hospitalization, severe clinical complications, and mortality due to influenza infection. We found that γδ T cells protected neonatal mice against mortality during influenza infection. γδ T cell deficiency did not alter viral clearance or interferon-γ production. Instead, neonatal influenza infection induced the accumulation of interleukin-17A (IL-17A)-producing γδ T cells, which was associated with IL-33 production by lung epithelial cells. Neonates lacking IL-17A-expressing γδ T cells or Il33 had higher mortality upon influenza infection. γδ T cells and IL-33 promoted lung infiltration of group 2 innate lymphoid cells and regulatory T cells, resulting in increased amphiregulin secretion and tissue repair. In influenza-infected children, IL-17A, IL-33, and amphiregulin expression were correlated, and increased IL-17A levels in nasal aspirates were associated with better clinical outcomes. Our results indicate that γδ T cells are required in influenza-infected neonates to initiate protective immunity and mediate lung homeostasis. Influenza infection causes mortality in infants and protective immunity in this population is poorly understood. Guo et al. find that γδ T cells are required for recovery after neonatal influenza infection. γδ T cell-derived IL-17A is associated with the tissue repair response orchestrated by IL-33, ILC2s, and amphiregulin, and IL-17A correlates with improved disease outcomes in influenza-infected children.