Publication: Ultrastructural changes in the intestinal absorptive cells of the mouse induced by capsaicin in relation to thiamine absorption
Issued Date
1996-03-01
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ISSN
0951418X
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2-s2.0-0029935082
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Mahidol University
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SCOPUS
Bibliographic Citation
Phytotherapy Research. Vol.10, No.2 (1996), 136-139
Suggested Citation
Chaitip Wanichanon, Panadda Hatthachote, Chaivat Toskulkao, Porncharn Saitongdee Ultrastructural changes in the intestinal absorptive cells of the mouse induced by capsaicin in relation to thiamine absorption. Phytotherapy Research. Vol.10, No.2 (1996), 136-139. doi:10.1002/(SICI)1099-1573(199603)10:2<136::AID-PTR789>3.0.CO;2-D Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/17580
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Title
Ultrastructural changes in the intestinal absorptive cells of the mouse induced by capsaicin in relation to thiamine absorption
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Abstract
The correlation between an inhibition of thiamine absorption and ultrastructural changes in the intestinal absorptive cells of the mouse jejunum induced by capsaicin was examined. In mice fed with capsaicin 1 and 2 mg/ kg BW/day for 12 weeks, thiamine absorption was inhibited by 2.7% and 12.5% (p < 0.001) respectively. Ultrastructural alterations were observed in villus absorptive cells of jejunum in mice fed with capsaicin 1 and 2 mg/kg BW/day for 12 weeks. The most striking ultrastructural changes occurred in mice fed with capsaicin 2 mg/kg BW/day for 12 weeks. The organelle most affected by capsaicin was the mitochondria. The result shows that the ultrastructural changes of intestinal absorptive cells may be associated with the inhibition of thiamine absorption.