Publication:
Two nonrecombining sympatric forms of the human malaria parasite plasmodium ovale occur globally

Issued Date

2010-05-15

Resource Type

Article

ISSN

00221899

DOI

10.1086/652240

Other identifier(s)

2-s2.0-77951891892

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Journal of Infectious Diseases. Vol.201, No.10 (2010), 1544-1550

Suggested Citation

Colin J. Sutherland, Naowarat Tanomsing, Debbie Nolder, Mary Oguike, Charlie Jennison, Sasithon Pukrittayakamee, Christiane Dolecek, Tran Tinh Hien, Virgilio E. Do Rosário, Ana Paula Arez, João Pinto, Pascal Michon, Ananias A. Escalante, Francois Nosten, Martina Burke, Rogan Lee, Marie Blaze, Thomas Dan Otto, John W. Barnwell, Arnab Pain, John Williams, Nicholas J. White, Nicholas P.J. Day, Georges Snounou, Peter J. Lockhart, Peter L. Chiodini, Mallika Imwong, Spencer D. Polley Two nonrecombining sympatric forms of the human malaria parasite plasmodium ovale occur globally. Journal of Infectious Diseases. Vol.201, No.10 (2010), 1544-1550. doi:10.1086/652240 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/29660

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Title

Two nonrecombining sympatric forms of the human malaria parasite plasmodium ovale occur globally

Author(s)

Colin J. Sutherland
 Naowarat Tanomsing
 Debbie Nolder
 Mary Oguike
 Charlie Jennison
 Sasithon Pukrittayakamee
 Christiane Dolecek
 Tran Tinh Hien
 Virgilio E. Do Rosário
 Ana Paula Arez
 João Pinto
 Pascal Michon
 Ananias A. Escalante
 Francois Nosten
 Martina Burke
 Rogan Lee
 Marie Blaze
 Thomas Dan Otto
 John W. Barnwell
 Arnab Pain
 John Williams
 Nicholas J. White
 Nicholas P.J. Day
 Georges Snounou
 Peter J. Lockhart
 Peter L. Chiodini
 Mallika Imwong
 Spencer D. Polley

Other Contributor(s)

Health Protection Agency
 London School of Hygiene & Tropical Medicine
 UCL
 Churchill Hospital
 Sanger Genome Centre
 Mahidol University
 Royal Institute
 Shoklo Malaria Research Unit
 University of Oxford
 Universidade Nova de Lisboa, Instituto de Higiene e Medicina Tropical
 Papua New Guinea Institute of Medical Research
 Arizona State University
 Centers for Disease Control and Prevention
 Westmead Hospital
 Inserm
 Faculte de Medecine Pierre et Marie Curie
 National University of Singapore
 Massey University

Abstract

Background. Malaria in humans is caused by apicomplexan parasites belonging to 5 species of the genus Plasmodium. Infections with Plasmodium ovale are widely distributed but rarely investigated, and the resulting burden of disease is not known. Dimorphism in defined genes has led to P ovale parasites being divided into classic and variant types. We hypothesized that these dimorphs represent distinct parasite species. Methods. Multilocus sequence analysis of 6 genetic characters was carried out among 55 isolates from 12 African and 3 Asia-Pacific countries. Results. Each genetic character displayed complete dimorphism and segregated perfectly between the 2 types. Both types were identified in samples from Ghana, Nigeria, São Tomé, Sierra Leone, and Uganda and have been described previously in Myanmar. Splitting of the 2 lineages is estimated to have occurred between 1.0 and 3.5 million years ago in hominid hosts. Conclusions. We propose that P ovale comprises 2 nonrecombining species that are sympatric in Africa and Asia. We speculate on possible scenarios that could have led to this speciation. Furthermore, the relatively high frequency of imported cases of symptomatic P ovale infection in the United Kingdom suggests that the morbidity caused by ovale malaria has been underestimated. © 2010 by the Infectious Diseases Society of America. All rights reserved.

Keyword(s)

Medicine

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URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/29660

Collections

Scopus 2006-2010