Publication: Intestinal mucosal defense system, Part 1. Consensus recommendations for immunonutrients
Issued Date
2013-04-02
Resource Type
ISSN
10976833
00223476
00223476
Other identifier(s)
2-s2.0-84875470934
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Pediatrics. Vol.162, No.3 SUPPL. (2013)
Suggested Citation
Josef Neu, Walter A. Mihatsch, Jaime Zegarra, Sarayut Supapannachart, Zong Yi Ding, Teresa Murguía-Peniche Intestinal mucosal defense system, Part 1. Consensus recommendations for immunonutrients. Journal of Pediatrics. Vol.162, No.3 SUPPL. (2013). doi:10.1016/j.jpeds.2012.11.054 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/32401
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Title
Intestinal mucosal defense system, Part 1. Consensus recommendations for immunonutrients
Abstract
When microbial communities colonize in the developing intestinal tract after birth, microrganisms interact with specific apical surface receptors on the enterocytes. This interaction triggers a response that prevents overexpression of inflammatory cytokines, thus providing protection from pathogen-induced mucosal damage. Multiple immune modulatory factors in human milk and innate humoral factors also control inflammatory responses, providing additional protective effects. Our understanding of the role of the luminal microbial communities or microbiota is growing rapidly as novel technologies provide new insights into their taxonomy, function during early development, and impact on life-long health. Multiple studies have evaluated the effects of the specific nutrients, glutamine, arginine, nucleotides, polyunsaturated fatty acids, and lactoferrin, on disease outcomes in premature infants. These studies support a role for nutrients to modulate host defense mechanisms in premature infants, to develop normal digestive function, to protect from bacterial translocation, and to preserve mucosal barrier integrity. These effects are clearly important. However, not enough is yet known to design specific clinical care practices that support a healthy microbiota.