Publication: Phase of menstrual cycle affects lysine requirement in healthy women
Issued Date
2004-09-01
Resource Type
ISSN
01931849
Other identifier(s)
2-s2.0-4143062437
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
American Journal of Physiology - Endocrinology and Metabolism. Vol.287, No.3 50-3 (2004)
Suggested Citation
Wantanee Kriengsinyos, Linda J. Wykes, Laksiri A. Goonewardene, Ronald O. Ball, Paul B. Pencharz Phase of menstrual cycle affects lysine requirement in healthy women. American Journal of Physiology - Endocrinology and Metabolism. Vol.287, No.3 50-3 (2004). doi:10.1152/ajpendo.00262.2003 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/21163
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Phase of menstrual cycle affects lysine requirement in healthy women
Abstract
The aim of this study was to investigate whether the phases of the menstrual cycle affect lysine requirement in healthy adult females, as determined by the indicator amino acid oxidation (IAAO) method. Five healthy females with regular menstrual cycles were studied at seven graded levels of lysine intake, in random order, with an oral [13C]phenylalanine tracer protocol in both the follicular and luteal phases. A total of 14 studies were conducted for each subject. Breath and plasma samples were collected according to the standard IAAO protocol. Serum 17β-estradiol and progesterone concentrations were measured on each IAAO study day. The rate of release of 13CO2 from [13C]phenylalanine oxidation (F13CO2) was measured, and a two-phase linear regression crossover model was applied to determine lysine requirement. F 13CO2 was higher during the luteal phase (P < 0.001) and was positively associated with serum concentrations of 17β-radiol and progesterone. The F13CO2 data were adjusted for subjects and sex hormones and used to define breakpoints for lysine requirements. The lysine requirement of healthy females in the luteal phase was 37.7 mg·kg-1·day-1 and higher (P = 0.025) than that of females in the follicular phase (35.0 mg·kg -1·day-1). At all lysine intake levels, plasma amino acids were lower and phenylalanine oxidation was higher in the luteal relative to the follicular phase. Therefore, we reason that the higher lysine requirement observed in the luteal phase is probably due to higher amino acid catabolism.