Publication: [6]-Gingerol-loaded cellulose acetate electrospun fibers as a topical carrier for controlled release
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Issued Date
2014-01-01
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01700839
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2-s2.0-84920082508
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Mahidol University
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SCOPUS
Bibliographic Citation
Polymer Bulletin. Vol.71, No.12 (2014), 3163-3176
Suggested Citation
Thanaporn Chantarodsakun, Thammasit Vongsetskul, Kulachart Jangpatarapongsa, Patoomratana Tuchinda, Sukanda Uamsiri, Chuthamas Bamrungcharoen, Supeecha Kumkate, Pakorn Opaprakasit, Pramuan Tangboriboonrat [6]-Gingerol-loaded cellulose acetate electrospun fibers as a topical carrier for controlled release. Polymer Bulletin. Vol.71, No.12 (2014), 3163-3176. doi:10.1007/s00289-014-1243-x Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/33667
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Title
[6]-Gingerol-loaded cellulose acetate electrospun fibers as a topical carrier for controlled release
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Abstract
© 2014, Springer-Verlag Berlin Heidelberg. [6]-Gingerol (6 % w/v)-loaded cellulose acetate (12 % w/v CA; MW ~ 3 × 104 g/mol) fibers (375 ± 107 nm) were prepared by electrospinning at 7.5 kV. ATR-FTIR spectra indicated that the mixture was miscible at this composition. Differential scanning calorimetry revealed that [6]-gingerol was uniformly dispersed in the CA matrix and interrupted the hydrogen bond formation among the CA chains. Controlled release study showed that ~97 % of the loaded [6]-gingerol could be released from the loaded fibers to the acetate buffer solution at 37 °C, whereas only ~74 % of it could be done from the corresponding films. About 92 % of [6]-gingerol in the fibers was dramatically released within 4 h. Release was mainly governed by a diffusion-controlled mechanism. The radical scavenging assay showed antioxidant activity of the loaded fibers. The in vitro cytotoxicity test revealed that the viability of L-929 mouse fibroblast cells to the loaded fibers was ~65 %.