Publication: Antibody-mediated complement C3b/iC3b binding to group B streptococcus in paired mother and baby serum samples in a refugee population on the Thailand-Myanmar border
Issued Date
2015-01-01
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ISSN
1556679X
15566811
15566811
Other identifier(s)
2-s2.0-84923864119
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Mahidol University
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SCOPUS
Bibliographic Citation
Clinical and Vaccine Immunology. Vol.22, No.3 (2015), 319-326
Suggested Citation
Jenny Herbert, Stephen Thomas, Charlotte Brookes, Claudia Turner, Paul Turnerd, Francois Nostend, Kirsty Le Doare, Michael Hudson, Paul T. Heath, Andrew Gorringe, Stephen Taylor Antibody-mediated complement C3b/iC3b binding to group B streptococcus in paired mother and baby serum samples in a refugee population on the Thailand-Myanmar border. Clinical and Vaccine Immunology. Vol.22, No.3 (2015), 319-326. doi:10.1128/CVI.00803-14 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/35650
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Title
Antibody-mediated complement C3b/iC3b binding to group B streptococcus in paired mother and baby serum samples in a refugee population on the Thailand-Myanmar border
Abstract
Copyright © 2015 American Society for Microbiology. All Rights Reserved. Streptococcus agalactiae (group B streptococcus [GBS]) is the leading cause of neonatal sepsis and meningitis. In this study, we determined antibody-mediated deposition of complement C3b/iC3b onto the bacterial cell surface of GBS serotypes Ia, Ib, II, III, and V. This was determined for 520 mother and umbilical cord serum sample pairs obtained at the time of birth from a population on the Thailand-Myanmar border. Antibody-mediated deposition of complement C3b/iC3b was detected to at least one serotype in 91% of mothers, despite a known carriage rate in this population of only 12%. Antibody-mediated C3b/iC3b deposition corresponded to known carriage rates, with the highest levels of complement deposition observed onto the most prevalent serotype (serotype II) followed by serotypes Ia, III, V, and Ib. Finally, neonates born to mothers carrying serotype II GBS at the time of birth showed higher antibody-mediated C3b/iC3b deposition against serotype II GBS than neonates born to mothers with no serotype II carriage. Assessment of antibody-mediated C3b/iC3b deposition against GBS may provide insights into the seroepidemiology of anti-GBS antibodies in mothers and infants in different populations.