Publication: Comparison of oral artemether and mefloquine in acute uncomplicated falciparum malaria
dc.contributor.author | J. Karbwang | en_US |
dc.contributor.author | K. Na Bangchang | en_US |
dc.contributor.author | A. Thanavibul | en_US |
dc.contributor.author | D. Bunnag | en_US |
dc.contributor.author | T. Chongsuphajaisiddhi | en_US |
dc.contributor.author | T. Harinasuta | en_US |
dc.contributor.other | Mahidol University | en_US |
dc.date.accessioned | 2018-08-10T08:46:40Z | |
dc.date.available | 2018-08-10T08:46:40Z | |
dc.date.issued | 1992-11-21 | en_US |
dc.description.abstract | Plasmodium falciparum malaria in Thailand is highly resistant to available antimalarials, and alternative drugs are needed urgently. Artemether is effective against falciparum malaria but associated with a high recrudescence rate. The proper dosage regimen remains to be defined. We have done a clinical trial comparing mefloquine 1250 mg in divided doses with oral artemether at 700 mg total dose given over 5 days in acute uncomplicated falciparum malaria. 46 patients, admitted to the Bangkok Hospital for Tropical Diseases, were randomised to receive either mefloquine (12) or artemether (34). Hospital follow-up was 28 days for the artemether group and 42 days for the mefloquine group. Oral artemether gave a significantly faster parasite clearance time than mefloquine (30 vs 64 h), and a significantly better cure rate (97 vs 64%) with fewer episodes of dizziness and vomiting. Oral artemether at 700 mg given over 5 days is effective and well tolerated. The cure rate with this regimen is higher than that reported by previous studies with 600 mg intramuscular artemether given over 5 days. Oral artemether can be considered as an alternative drug for multiple-drug-resistant falciparum malaria. © 1992. | en_US |
dc.identifier.citation | The Lancet. Vol.340, No.8830 (1992), 1245-1248 | en_US |
dc.identifier.doi | 10.1016/0140-6736(92)92947-E | en_US |
dc.identifier.issn | 01406736 | en_US |
dc.identifier.other | 2-s2.0-0026494672 | en_US |
dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/123456789/22368 | |
dc.rights | Mahidol University | en_US |
dc.rights.holder | SCOPUS | en_US |
dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0026494672&origin=inward | en_US |
dc.subject | Medicine | en_US |
dc.title | Comparison of oral artemether and mefloquine in acute uncomplicated falciparum malaria | en_US |
dc.type | Article | en_US |
dspace.entity.type | Publication | |
mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0026494672&origin=inward | en_US |