Publication: Bone mineral density in long-term depot medroxyprogesterone acetate acceptors
Issued Date
1997-07-01
Resource Type
ISSN
00107824
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2-s2.0-0030886564
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Mahidol University
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SCOPUS
Bibliographic Citation
Contraception. Vol.56, No.1 (1997), 1-3
Suggested Citation
Surasak Taneepanichskul, Suwachai Intaraprasert, Urusa Theppisai, Kamhaeng Chaturachinda Bone mineral density in long-term depot medroxyprogesterone acetate acceptors. Contraception. Vol.56, No.1 (1997), 1-3. doi:10.1016/S0010-7824(97)00066-8 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/18113
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Title
Bone mineral density in long-term depot medroxyprogesterone acetate acceptors
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Abstract
The study of bone density in long-term DMPA users is reported. The aims were to study and compare bone density in long-term DMPA users with intrauterine device (IUD) users. Fifty current users of DMPA with a minimum 36 months previous use were compared to 50 current IUD users as control. The bone mineral density was measured by dual energy x-ray absorptiometry (DEXA) at the non-dominant distal and ultradistal forearm. Serum estradiol was measured by microparticle enzyme immunoassay technique in both groups. Age, income, weight, height, BMI, and parity of both groups were matched. The mean bone mineral density of distal forearm in DMPA and IUD users was 0.48 ± 0.05 g/cm2in both groups. The mean bone mineral density of ultradistal forearm was 0.38 ± 0.06 g/cm2in DMPA users and 0.4 ± 0.05 g/cm2in IUD users. No differences in mean bone mineral density of distal and ultradistal forearm between DMPA and IUD users was demonstrated (95% CI -0.02, 0.02 and -0.04, 0.001, respectively). However, the serum estradiol levels were significantly different between DMPA and IUD users (95% CI -122, -68.1). From this study, it is suggested that long-term DMPA use should not have any adverse effect on bone density even if it reduces serum estradiol.