Publication: Inflammatory lesions of the spine on magnetic resonance imaging predict the development of new syndesmophytes in ankylosing spondylitis evidence of a relationship between inflammation and new bone formation
dc.contributor.author | Walter P. Maksymowych | en_US |
dc.contributor.author | Praveena Chiowchanwisawakit | en_US |
dc.contributor.author | Tracey Clare | en_US |
dc.contributor.author | Susanne J. Pedersen | en_US |
dc.contributor.author | Mikkel Østergaard | en_US |
dc.contributor.author | Robert G.W. Lambert | en_US |
dc.contributor.other | University of Alberta | en_US |
dc.contributor.other | Mahidol University | en_US |
dc.contributor.other | Copenhagen University Hospital | en_US |
dc.date.accessioned | 2018-09-13T06:45:01Z | |
dc.date.available | 2018-09-13T06:45:01Z | |
dc.date.issued | 2009-01-01 | en_US |
dc.description.abstract | Objective. To determine whether a vertebral corner that demonstrates an active corner inflammatory lesion (CIL) on magnetic resonance imaging (MRI) in patients with ankylosing spondylitis (AS) is more likely to evolve into a de novo syndesmophyte visible on plain radiography than is a vertebral corner that demonstrates no active inflammation on MRI. Methods. MRI scans and plain radiographs were obtained for 29 patients recruited into randomized placebo-controlled trials of anti-tumor necrosis factor α (anti-TNFα) therapy. MRI was conducted at baseline, 12 or 24 weeks (n = 29), and 2 years (n = 22), while radiography was conducted at baseline and 2 years. A persistent CIL was defined as a CIL that was found on all available scans. A resolved CIL was defined as having completely disappeared on either the second or third scan. A validation cohort consisted of 41 AS patients followed up prospectively. Anonymized MRIs were assessed independently by 3 readers who were blinded with regard to radiographic findings. Results. New syndesmophytes developed significantly more frequently in vertebral corners with inflammation (20%) than in those without inflammation (5.1%) seen on baseline MRI (P ≤ 0.008 for all reader pairs). They also developed more frequently in vertebral corners where inflammation had resolved than in those where inflammation persisted after anti-TNF treatment. This was confirmed in the analysis of the prospective cohort, in which significantly more vertebral corners with inflammation (14.3%) compared with those without inflammation (2.9%) seen on baseline MRI developed new syndesmophytes (P ≤ 0.003 for all reader pairs). Conclusion. Our findings indicate that a syndesmophyte is more likely to develop from a prior inflammatory lesion, supporting a relationship between inflammation and ankylosis. © 2009, American College of Rheumatology. | en_US |
dc.identifier.citation | Arthritis and Rheumatism. Vol.60, No.1 (2009), 93-102 | en_US |
dc.identifier.doi | 10.1002/art.24132 | en_US |
dc.identifier.issn | 15290131 | en_US |
dc.identifier.issn | 00043591 | en_US |
dc.identifier.other | 2-s2.0-58249103888 | en_US |
dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/123456789/27750 | |
dc.rights | Mahidol University | en_US |
dc.rights.holder | SCOPUS | en_US |
dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=58249103888&origin=inward | en_US |
dc.subject | Immunology and Microbiology | en_US |
dc.subject | Medicine | en_US |
dc.title | Inflammatory lesions of the spine on magnetic resonance imaging predict the development of new syndesmophytes in ankylosing spondylitis evidence of a relationship between inflammation and new bone formation | en_US |
dc.type | Article | en_US |
dspace.entity.type | Publication | |
mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=58249103888&origin=inward | en_US |