Publication: Antibodies to a single, conserved epitope in anopheles APN1 inhibit universal transmission of plasmodium falciparum and plasmodium vivax malaria
Issued Date
2014-02-01
Resource Type
ISSN
10985522
00199567
00199567
Other identifier(s)
2-s2.0-84893008833
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Infection and Immunity. Vol.82, No.2 (2014), 818-829
Suggested Citation
Jennifer S. Armistead, Isabelle Morlais, Derrick K. Mathias, Juliette G. Jardim, Jaimy Joy, Arthur Fridman, Adam C. Finnefrock, Ansu Bagchi, Magdalena Plebanski, Diana G. Scorpio, Thomas S. Churcher, Natalie A. Borg, Jetsumon Sattabongkot, Rhoel R. Dinglasana Antibodies to a single, conserved epitope in anopheles APN1 inhibit universal transmission of plasmodium falciparum and plasmodium vivax malaria. Infection and Immunity. Vol.82, No.2 (2014), 818-829. doi:10.1128/IAI.01222-13 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/33998
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Title
Antibodies to a single, conserved epitope in anopheles APN1 inhibit universal transmission of plasmodium falciparum and plasmodium vivax malaria
Abstract
Malaria transmission-blocking vaccines (TBVs) represent a promising approach for the elimination and eradication of this disease. AnAPN1 is a lead TBV candidate that targets a surface antigen on the midgut of the obligate vector of the Plasmodium parasite, the Anopheles mosquito. In this study, we demonstrated that antibodies targeting AnAPN1 block transmission of Plasmodium falciparum and Plasmodium vivax across distantly related anopheline species in countries to which malaria is endemic. Using a biochemical and immunological approach, we determined that the mechanism of action for this phenomenon stems from antibody recognition of a single protective epitope on AnAPN1, which we found to be immunogenic in murine and nonhuman primate models and highly conserved among anophelines. These data indicate that AnAPN1 meets the established target product profile for TBVs and suggest a potential key role for an AnAPN1-based panmalaria TBV in the effort to eradicate malaria.© 2014, American Society for Microbiology.