Publication: Comparison of phosphatidylserine-exposing red blood cells, fragmented red blood cells and red blood cell-derived microparticles in β-thalassemia/HBE patients
Issued Date
2019-02-01
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ISSN
19437730
00075027
00075027
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2-s2.0-85058924679
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Mahidol University
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SCOPUS
Bibliographic Citation
Lab Medicine. Vol.50, No.1 (2019), 47-53
Suggested Citation
Egarit Noulsri, Sakkarin Ardsiri, Surada Lerdwana, Kovit Pattanapanyasat Comparison of phosphatidylserine-exposing red blood cells, fragmented red blood cells and red blood cell-derived microparticles in β-thalassemia/HBE patients. Lab Medicine. Vol.50, No.1 (2019), 47-53. doi:10.1093/labmed/lmy039 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/50263
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Title
Comparison of phosphatidylserine-exposing red blood cells, fragmented red blood cells and red blood cell-derived microparticles in β-thalassemia/HBE patients
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Abstract
© American Society for Clinical Pathology 2018. All rights reserved. Objective: To determine the number and intensity of phosphatidylserine (PS) expression of the red blood cells (RBCs), fragmented RBCs, and RBC-derived microparticles (RMPs) in patients with β-thalassemia/ hemoglobin (Hb)E. Methods: We used flow cytometry to determine the number and levels of PS expression. Results: The number of PS-exposing RBCs was statistically significantly higher (P <.001) than that of PS-exposing fragmented RBCs or RMPs. In contrast, the intensity of PS expression was significantly higher (P <.001) in RMPs than in RBCs or fragmented RBCs. Our study showed a trend of association between RBC distribution width (RDW) and both the number of fragmented RBCs and RMPs and their intensity of PS expression. Conclusion: In β-thalassemia/HbE, PS-exposing RBCs, fragmented RBCs, and RMPs all differed in their numbers and their intensity of PS expression. The effects of these differences among PS-exposing populations on the pathophysiology of the disease require further investigation.