Publication: Antimicrobial resistance in Clostridium difficile ribotype 017
2
Issued Date
2020-01-02
Resource Type
ISSN
17448336
14787210
14787210
Other identifier(s)
2-s2.0-85076421561
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Mahidol University
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SCOPUS
Bibliographic Citation
Expert Review of Anti-Infective Therapy. Vol.18, No.1 (2020), 17-25
Suggested Citation
Korakrit Imwattana, Daniel R. Knight, Brian Kullin, Deirdre A. Collins, Papanin Putsathit, Pattarachai Kiratisin, Thomas V. Riley Antimicrobial resistance in Clostridium difficile ribotype 017. Expert Review of Anti-Infective Therapy. Vol.18, No.1 (2020), 17-25. doi:10.1080/14787210.2020.1701436 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/49620
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Title
Antimicrobial resistance in Clostridium difficile ribotype 017
Abstract
© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. Introduction: Antimicrobial resistance (AMR) played an important role in the initial outbreaks of Clostridium difficile infection (CDI) in the 1970s. C. difficile ribotype (RT) 017 has emerged as the major strain of C. difficile in Asia, where antimicrobial use is poorly regulated. This strain has also caused CDI outbreaks around the world for almost 30 years. Many of these outbreaks were associated with clindamycin and fluoroquinolone resistance. AMR and selective pressure is likely to be responsible for the success of this RT and may drive future outbreaks. Areas covered: This narrative review summarizes the prevalence and mechanisms of AMR in C. difficile RT 017 and transmission of these AMR mechanisms. To address these topics, reports of outbreaks due to C. difficile RT 017, epidemiologic studies with antimicrobial susceptibility results, studies on resistance mechanisms found in C. difficile and related publications available through Pubmed until September 2019 were collated and the findings discussed. Expert opinion: Primary prevention is the key to control CDI. This should be achieved by developing antimicrobial stewardship in medical, veterinary and agricultural practices. AMR is the key factor that drives CDI outbreaks, and methods for the early detection of AMR can facilitate the control of outbreaks.