Publication: Prevalence of small airways dysfunction in asthma with-and without-fixed airflow obstruction and chronic obstructive pulmonary disease
2
Issued Date
2021-12-01
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ISSN
22288694
0125877X
0125877X
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2-s2.0-85096637576
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Mahidol University
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SCOPUS
Bibliographic Citation
Asian Pacific Journal of Allergy and Immunology. Vol.39, No.4 (2021), 296-303
Suggested Citation
Prapaporn Pornsuriyasak, Supattra Khiawwan, Sasivimol Rattanasiri, Nattawut Unwanatham, Tananchai Petnak Prevalence of small airways dysfunction in asthma with-and without-fixed airflow obstruction and chronic obstructive pulmonary disease. Asian Pacific Journal of Allergy and Immunology. Vol.39, No.4 (2021), 296-303. doi:10.12932/AP-310119-0485 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/77191
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Title
Prevalence of small airways dysfunction in asthma with-and without-fixed airflow obstruction and chronic obstructive pulmonary disease
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Abstract
Background: Small airways dysfunction (SAD) is not uncommon in asthma without fixed airflow obstruction (FAO). Objectives: We aimed to determine if SAD in non-FAO asthma is different from FAO-asthma and COPD. Methods: Cases of obstructive airway diseases who underwent spirometry, plethysmography, and impulse oscillometry [resistance at 5 Hz (R5) and at 20 Hz (R20), peripheral resistance (R5-R20), and reactance area (AX)] were reviewed, and classified as; 1) COPD, 2) FAO-asthma, and 3) non-FAO asthma. FAO was defined as post-bronchodilator (post-BD) FEV1/FVC < 0.7. SAD was considered if 1) RV/TLC ≥ 40%, or 2) post-BD R5-R20 ≥ 0.075 kPa.L-1s. Results: A total of 73 patients (22 COPD, 24 FAO-asthma, and 27 non-FAO asthma) were analysed. RV/TLC ratio was higher in FAO-asthma and COPD (45 ± 5% and 42 ± 8%) than in non-FAO asthma (32 ± 8%), p < 0.001. Post-BD values of R5-R20 and AX (median; range) were higher in FAO-asthma (0.17; 0.08, 0.47, 13.24; 6.52, 82.11) than in non-FAO asthma (0.11; 0.03, 0.23, 8.63; 2.40, 22.02), p = 0.007 and p = 0.017, respectively. The prevalence of SAD among diagnosis group by RV/TLC criterion was different (95%, 59%, and 15% in FAO-asthma, COPD, and non-FAO asthma, p < 0.001), but those were not observed by R5-R20 criterion (95%, 68%, and 77%, p = 0.052). Conclusion: SAD in non-FAO asthma was less prevalent than FAO-asthma and COPD.