Publication: Propensity-adjusted comparison of mortality of elderly versus very elderly ventilated patients
Issued Date
2021-05-01
Resource Type
ISSN
19433654
00201324
00201324
Other identifier(s)
2-s2.0-85106069446
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Respiratory Care. Vol.66, No.5 (2021), 814-821
Suggested Citation
Bernhard Wernly, Raphael Romano Bruno, Fernando Frutos-Vivar, Oscar Peñuelas, Richard Rezar, Konstantinos Raymondos, Alfonso Muriel, Bin Du, Arnaud W. Thille, Fernando Ríos, Marco González, Lorenzo Del-Sorbo, Maria Del Carmen Marín, Bruno Valle Pinheiro, Marco Antonio Soares, Nicolas Nin, Salvatore M. Maggiore, Andrew Bersten, Malte Kelm, Pravin Amin, Nahit Cakar, Gee Young Suh, Fekri Abroug, Manuel Jibaja, Dimitros Matamis, Amine Ali Zeggwagh, Yuda Sutherasan, Bertrand Guidet, Dylan W. De Lange, Michael Beil, Sigal Svri, Vernon van Heerden, Hans Flaatten, Antonio Anzueto, Venet Osmani, Andrés Esteban, Christian Jung Propensity-adjusted comparison of mortality of elderly versus very elderly ventilated patients. Respiratory Care. Vol.66, No.5 (2021), 814-821. doi:10.4187/RESPCARE.08547 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/78235
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Title
Propensity-adjusted comparison of mortality of elderly versus very elderly ventilated patients
Author(s)
Bernhard Wernly
Raphael Romano Bruno
Fernando Frutos-Vivar
Oscar Peñuelas
Richard Rezar
Konstantinos Raymondos
Alfonso Muriel
Bin Du
Arnaud W. Thille
Fernando Ríos
Marco González
Lorenzo Del-Sorbo
Maria Del Carmen Marín
Bruno Valle Pinheiro
Marco Antonio Soares
Nicolas Nin
Salvatore M. Maggiore
Andrew Bersten
Malte Kelm
Pravin Amin
Nahit Cakar
Gee Young Suh
Fekri Abroug
Manuel Jibaja
Dimitros Matamis
Amine Ali Zeggwagh
Yuda Sutherasan
Bertrand Guidet
Dylan W. De Lange
Michael Beil
Sigal Svri
Vernon van Heerden
Hans Flaatten
Antonio Anzueto
Venet Osmani
Andrés Esteban
Christian Jung
Raphael Romano Bruno
Fernando Frutos-Vivar
Oscar Peñuelas
Richard Rezar
Konstantinos Raymondos
Alfonso Muriel
Bin Du
Arnaud W. Thille
Fernando Ríos
Marco González
Lorenzo Del-Sorbo
Maria Del Carmen Marín
Bruno Valle Pinheiro
Marco Antonio Soares
Nicolas Nin
Salvatore M. Maggiore
Andrew Bersten
Malte Kelm
Pravin Amin
Nahit Cakar
Gee Young Suh
Fekri Abroug
Manuel Jibaja
Dimitros Matamis
Amine Ali Zeggwagh
Yuda Sutherasan
Bertrand Guidet
Dylan W. De Lange
Michael Beil
Sigal Svri
Vernon van Heerden
Hans Flaatten
Antonio Anzueto
Venet Osmani
Andrés Esteban
Christian Jung
Other Contributor(s)
Ramathibodi Hospital
South Texas Veterans Health Care System
Hospital Regional 1° de Octubre ISSSTE
Bruno Kessler Foundation
CHU Fattouma-Bourguiba
University Medical Center Utrecht
Haukeland Universitetssjukehus
Heinrich-Heine-Universität Düsseldorf
Medizinische Hochschule Hannover (MHH)
Hospital Ramon y Cajal
Centre Hospitalier Universitaire de Poitiers
Samsung Medical Center, Sungkyunkwan University
Flinders University
Mohammed V University in Rabat
University of Toronto
Paracelsus Medizinische Privatuniversitat
Papageorgiou General Hospital
İstanbul Tıp Fakültesi
Bombay Hospital and Medical Research Centre
Peking Union Medical College Hospital
Hospital Nacional Professor Dr. Alejandro Posadas
University of G. d'Annunzio Chieti and Pescara
Hospital Universitario de Getafe
Sorbonne Universite
Universidade Federal de Juiz de Fora
Hadassah University Medical Centre
Clínica Medellín & Universidad Pontificia Bolivari-ana
Hospital Universitario de Montevideo
Hospital de Especialidades Eugenio Espejo
Hospital Universitario Sao Jose
South Texas Veterans Health Care System
Hospital Regional 1° de Octubre ISSSTE
Bruno Kessler Foundation
CHU Fattouma-Bourguiba
University Medical Center Utrecht
Haukeland Universitetssjukehus
Heinrich-Heine-Universität Düsseldorf
Medizinische Hochschule Hannover (MHH)
Hospital Ramon y Cajal
Centre Hospitalier Universitaire de Poitiers
Samsung Medical Center, Sungkyunkwan University
Flinders University
Mohammed V University in Rabat
University of Toronto
Paracelsus Medizinische Privatuniversitat
Papageorgiou General Hospital
İstanbul Tıp Fakültesi
Bombay Hospital and Medical Research Centre
Peking Union Medical College Hospital
Hospital Nacional Professor Dr. Alejandro Posadas
University of G. d'Annunzio Chieti and Pescara
Hospital Universitario de Getafe
Sorbonne Universite
Universidade Federal de Juiz de Fora
Hadassah University Medical Centre
Clínica Medellín & Universidad Pontificia Bolivari-ana
Hospital Universitario de Montevideo
Hospital de Especialidades Eugenio Espejo
Hospital Universitario Sao Jose
Abstract
BACKGROUND: The growing proportion of elderly intensive care patients constitutes a public health challenge. The benefit of critical care in these patients remains unclear. We compared outcomes in elderly versus very elderly subjects receiving mechanical ventilation. METHODS: In total, 5,557 mechanically ventilated subjects were included in our post hoc retrospective anal-ysis, a subgroup of the VENTILA study. We divided the cohort into 2 subgroups on the basis of age: very elderly subjects (age ≥ 80 y; n = 1,430), and elderly subjects (age 65–79 y; n = 4,127). A propensity score on being very elderly was calculated. Evaluation of associations with 28-d mortality was done with logistic regression analysis. RESULTS: Very elderly subjects were clinically sicker as expressed by higher SAPS II scores (53 ± 18 vs 50 ± 18, P <.001), and their rates of plateau pressure < 30 cm H2O were higher, whereas other parameters did not differ. The 28-d mortality was higher in very elderly subjects (42% vs 34%, P <.001) and remained unchanged after propensity score adjustment (adjusted odds ratio 1.31 [95% CI 1.16–1.49], P <.001). CONCLUSIONS: Age was an independent and unchangeable risk factor for death in mechanically ventilated subjects. However, survival rates of very elderly subjects were > 50%. Denial of critical care based solely on age is not justified.