Publication: Cytotoxicity against cholangiocarcinoma and HepG2 cell lines of lignan derivatives from Hernandia nymphaeifolia
| dc.contributor.author | Jittra Suthiwong | en_US |
| dc.contributor.author | Jaroon Wandee | en_US |
| dc.contributor.author | Siripit Pitchuanchom | en_US |
| dc.contributor.author | Punchapat Sojikul | en_US |
| dc.contributor.author | Veerapol Kukongviriyapan | en_US |
| dc.contributor.author | Chavi Yenjai | en_US |
| dc.contributor.other | Faculty of Medicine, Khon Kaen University | en_US |
| dc.contributor.other | Khon Kaen University | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | Mahasarakham University | en_US |
| dc.date.accessioned | 2019-08-23T10:49:27Z | |
| dc.date.available | 2019-08-23T10:49:27Z | |
| dc.date.issued | 2018-08-01 | en_US |
| dc.description.abstract | © 2018, Springer Science+Business Media, LLC, part of Springer Nature. Twelve lignan derivatives were synthesized from deoxypodophyllotoxin isolated from Hernandia nymphaeifolia. Cytotoxicity evaluation against cholangiocarcinoma, KKU-100, and HepG2 cell lines showed that compounds 3, 9, 10, and 13 exhibited stronger cytotoxicity than the starting material, 1, with IC 50 ranging from 0.42 to 2.01 μM. Compound 10 displayed interesting activity by showing IC 50 values of 0.75 and 0.46 μM against KKU-100 and HepG2 cell lines, respectively. From these observation, 10 seems to be useful as a lead compound for the development of anticancer agents. | en_US |
| dc.identifier.citation | Medicinal Chemistry Research. Vol.27, No.8 (2018), 2042-2049 | en_US |
| dc.identifier.doi | 10.1007/s00044-018-2214-9 | en_US |
| dc.identifier.issn | 15548120 | en_US |
| dc.identifier.issn | 10542523 | en_US |
| dc.identifier.other | 2-s2.0-85049671953 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/45486 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85049671953&origin=inward | en_US |
| dc.subject | Chemistry | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | Cytotoxicity against cholangiocarcinoma and HepG2 cell lines of lignan derivatives from Hernandia nymphaeifolia | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85049671953&origin=inward | en_US |