Publication: Preoperative chemoradiation for locally advanced rectal cancer with capecitabine 2,000 mg/m<sup>2</sup>/day
Issued Date
2008-10-01
Resource Type
ISSN
01252208
01252208
01252208
Other identifier(s)
2-s2.0-55249087415
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.91, No.10 (2008), 1583-1588
Suggested Citation
Vutisiri Veerasarn, Wiroon Boonnuch, Vitoon Chinswangwatanakul, Darin Lohsiriwat, Pranee Mahamadsolaeh Preoperative chemoradiation for locally advanced rectal cancer with capecitabine 2,000 mg/m<sup>2</sup>/day. Journal of the Medical Association of Thailand. Vol.91, No.10 (2008), 1583-1588. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/19513
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Preoperative chemoradiation for locally advanced rectal cancer with capecitabine 2,000 mg/m<sup>2</sup>/day
Other Contributor(s)
Abstract
Objective: Evaluate the efficacy and the tolerability of preoperative chemoradiation with high dose Capecitabine. Material and Method: Fifteen patients with locally advanced resectable rectal cancer were treated with Capecitabine 2,000 mg/m2/day, orally 7 days/week concurrent with whole pelvic irradiation 45 Gy in 25 fractions/5 weeks. Patients underwent surgery in the following 4-6 weeks. Results: After complete treatment, 11 patients (73%) underwent surgery. Ten patients (66%) had sphincter preservative surgery; three of them had primary tumors located in the lower rectum. Five patients had grade 2 and one patient had grade 3 diarrhea. No grade 4 toxicity was reported. Conclusion: Preoperative Capecitabine 2,000 mg/m2/day concurrent with whole pelvic irradiation were effective and well tolerated. The potential dose limiting toxicity effect was the diarrhea.