Publication:
Repeated exposure to opisthorchis viverrini and treatment with the antihelminthic praziquantel lacks carcinogenic potential

Issued Date

1992-02-01

Resource Type

Article

ISSN

01433334

DOI

10.1093/carcin/13.2.309

Other identifier(s)

2-s2.0-0026567040

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Carcinogenesis. Vol.13, No.2 (1992), 309-311

Suggested Citation

Witaya Thamavit, Malcolm A. Moore, Somsak Ruchirawat, Nobuyuki Ito Repeated exposure to opisthorchis viverrini and treatment with the antihelminthic praziquantel lacks carcinogenic potential. Carcinogenesis. Vol.13, No.2 (1992), 309-311. doi:10.1093/carcin/13.2.309 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22258

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Title

Repeated exposure to opisthorchis viverrini and treatment with the antihelminthic praziquantel lacks carcinogenic potential

Author(s)

Witaya Thamavit
 Malcolm A. Moore
 Somsak Ruchirawat
 Nobuyuki Ito

Other Contributor(s)

Mahidol University
 Nagoya City University Medical School

Abstract

The effects of repeated Praziquantel administration, subsequent to infection and reinfection w Opisthorchis viverrini (OV), on lesion development in the Syrian hamster liver were investigated. Five applications of the antihelminthic drag were made (300 mg/kg body wt, i.g.), each time ∼5 weeks after dosing with 60-80 OV metacercarine at weeks 0, 8, 16, 24 and 32. The animals were then maintained until week 40 when they were killed; histopathological investigation revealed no significant development of either hepatocellular of cholangiocellular preneoplastic/neoplastic lesions. The results indicate that repeated exposure to Praziquantel at levels sufficient for successful removal of parasite infestation does not itself carry carcinogenic risk. © 1992 Oxford University Press.

Keyword(s)

Biochemistry, Genetics and Molecular Biology

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/22258

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Scopus 1991-2000