Publication: Aspergillusol A, an α-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus
Issued Date
2009-11-30
Resource Type
ISSN
01633864
Other identifier(s)
2-s2.0-73349134679
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Natural Products. Vol.72, No.11 (2009), 2049-2052
Suggested Citation
Nattha Ingavat, Jeffrey Dobereiner, Suthep Wiyakrutta, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop Aspergillusol A, an α-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus. Journal of Natural Products. Vol.72, No.11 (2009), 2049-2052. doi:10.1021/np9003883 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/27114
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Title
Aspergillusol A, an α-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus
Abstract
A new tyrosine-derived metabolite, aspergillusol A (4), was isolated on a gram scale, together with a methyl ester of 4-hydroxyphenylpyruvic acid oxime (5) and secalonic acid A, from the marine-derived fungus Aspergillus aculeatus CRI323-04. The tetraol in 4 was identified as erythritol by comparison of the 1H NMR spectrum of its benzoylated derivative with those of benzoylated erythritol (7) and D-threitol (8), as well as by cellulose-based chiral HPLC analysis. Aspergillusol A (4) selectively inhibited α-glucosidase from the yeast Saccharomyces cerevisiae, but it was inactive toward the α-glucosidase from the bacterium Bacillus stearothermophilus. © 2009 American Chemical Society and American Society of Pharmacognosy.