Publication:
Development of tri-component copolymer rods as implantable drug delivery systems for liver cancer therapy

1

Issued Date

2009-12-01

Resource Type

Conference Paper

ISSN

16800737

DOI

10.1007/978-3-642-03887-7-92

Other identifier(s)

2-s2.0-77949877644

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

IFMBE Proceedings. Vol.25, No.8 (2009), 317-320

Suggested Citation

N. Nasongkla, P. Akarajiratun, S. Hongeng Development of tri-component copolymer rods as implantable drug delivery systems for liver cancer therapy. IFMBE Proceedings. Vol.25, No.8 (2009), 317-320. doi:10.1007/978-3-642-03887-7-92 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/27369

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Title

Development of tri-component copolymer rods as implantable drug delivery systems for liver cancer therapy

Author(s)

N. Nasongkla
 P. Akarajiratun
 S. Hongeng

Other Contributor(s)

Mahidol University

Abstract

Tri-component copolymers of poly(ε-caprolactone)- random-poly(D,L- lactide)-block-poly(ethylene glycol)-blockpoly( ε-caprolactone)-random- poly(D,L-lactide) (PLCA-PEGPLCA or PLEC) were used as a material to develop cylindrical polymeric rods and were used as the implantable drug delivery system. PLEC was successfully synthesized and the copolymer ratio and molecular weight were controllable. Trypan blue was selected as a model drug and the release profiles of trypan blue were carried out at 20 and 30 % loading. The release rate of trypan blue was found to directly depend on the amount of lactide in PLEC and the amount of trypan blue. © 2009 Springer-Verlag.

Keyword(s)

Chemical Engineering
 Engineering

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URI

https://repository.li.mahidol.ac.th/handle/123456789/27369

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Scopus 2006-2010