Publication:
Suppression of prometastatic phenotype of highly metastatic androgen-independent rat prostate cancer MLL cell line by PI3K inhibitor LY294002

2

Issued Date

2009-12-08

Resource Type

Article

ISSN

09650407

DOI

10.3727/096504009787721195

Other identifier(s)

2-s2.0-65649089560

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Oncology Research. Vol.17, No.7 (2009), 301-309

Suggested Citation

Chaiwat Prawettongsopon, Sariya Asawakarn, Tuangporn Suthiphongchai Suppression of prometastatic phenotype of highly metastatic androgen-independent rat prostate cancer MLL cell line by PI3K inhibitor LY294002. Oncology Research. Vol.17, No.7 (2009), 301-309. doi:10.3727/096504009787721195 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/27098

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Title

Suppression of prometastatic phenotype of highly metastatic androgen-independent rat prostate cancer MLL cell line by PI3K inhibitor LY294002

Author(s)

Chaiwat Prawettongsopon
 Sariya Asawakarn
 Tuangporn Suthiphongchai

Other Contributor(s)

Mahidol University
 Chulalongkorn University

Abstract

Upregulation of the PI3K pathway has often been reported in androgen-independent prostate cancer and is implicated in cancer cell survival and proliferation in the absence of androgen. Inhibition of PI3K by LY294002 suppressed cell invasion and motility of the highly metastatic androgen-independent Dunning rat prostate cancer MLL cell line with similar IC50 values and inhibition profile. Moreover, LY294002 attenuated expression of urokinase plasminogen activator (uPA) without any significant effect on that of matrix metalloproteinase 2. These results indicated that the role of PI3K in MLL cell invasion is by regulating cell motility and uPA expression. Copyright © 2009 Cognizant Comm. Corp. All rights reseved.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Medicine

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URI

https://repository.li.mahidol.ac.th/handle/123456789/27098

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