Publication: Evaluating the first introduction of rotavirus vaccine in Thailand: Moving from evidence to policy
Issued Date
2017-02-01
Resource Type
ISSN
18732518
0264410X
0264410X
Other identifier(s)
2-s2.0-85008423046
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Mahidol University
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SCOPUS
Bibliographic Citation
Vaccine. Vol.35, No.5 (2017), 796-801
Suggested Citation
Piyanit Tharmaphornpilas, Suchada Jiamsiri, Somchit Boonchaiya, Onwipa Rochanathimoke, Wiravan Thinyounyong, Sumana Tuntiwitayapun, Ratigorn Guntapong, Arthorn Riewpaiboon, Aim on Rasdjarmrearnsook, Roger I. Glass Evaluating the first introduction of rotavirus vaccine in Thailand: Moving from evidence to policy. Vaccine. Vol.35, No.5 (2017), 796-801. doi:10.1016/j.vaccine.2016.12.043 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/41969
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Title
Evaluating the first introduction of rotavirus vaccine in Thailand: Moving from evidence to policy
Abstract
© 2016 Elsevier Ltd Background We assessed the effectiveness and possible impact of introducing rotavirus vaccine into the routine immunization program. Methods Two provinces were selected for an observational study, one where vaccine was introduced and another where vaccine was not available. In these areas, two sub-studies were linked. The prospective cohort study enrolled children 2 month old and followed them to the age of 18 months to detect all diarrhea episodes. The hospital surveillance study enrolled all children up to age 5 hospitalized with diarrhea whose fecal samples were tested for rotavirus. Rates of rotavirus hospitalizations in older children who had not been vaccinated in both settings provided data to determine whether immunization had an indirect herd effect. The key endpoints for the study were both vaccine effectiveness (VE) based upon hospitalized rotavirus diarrhea and herd protection. Findings From the cohort study, the overall VE for hospitalized rotavirus diarrhea was 88% (95%CI 76–94). Data from hospital surveillance indicated that for 2 consecutive years, the seasonal peak of rotavirus admissions was no longer present in the vaccinated area. Herd protection was observed among older children born before the rotavirus vaccine program was introduced, who experienced a 40–69% reduction in admission for rotavirus. Conclusions Rotavirus vaccine was highly effective in preventing diarrheal hospitalizations and in conferring herd protection among older children who had not been vaccinated.