Publication: Genetic evaluation of the performance of malaria parasite clearance rate metrics
Issued Date
2013-07-15
Resource Type
ISSN
00221899
Other identifier(s)
2-s2.0-84879372761
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Infectious Diseases. Vol.208, No.2 (2013), 346-350
Suggested Citation
Standwell C. Nkhoma, Kasia Stepniewska, Shalini Nair, Aung Pyae Phyo, Rose McGready, François Nosten, Tim J.C. Anderson Genetic evaluation of the performance of malaria parasite clearance rate metrics. Journal of Infectious Diseases. Vol.208, No.2 (2013), 346-350. doi:10.1093/infdis/jit165 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/32261
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Title
Genetic evaluation of the performance of malaria parasite clearance rate metrics
Abstract
Accurate measurement of malaria parasite clearance rates (CRs) following artemisinin (ART) treatment is critical for resistance surveillance and research, and various CR metrics are currently used. We measured 13 CR metrics in 1472 ART-treated hyperparasitemia infections for which 6-hour parasite counts and parasite genotypes (93 single nucleotide polymorphisms [SNPs]) were available. We used heritability to evaluate the performance of each metric. Heritability ranged from 0.06 ± 0.06 (SD) for 50% parasite clearance times to 0.67 ± 0.04 (SD) for clearance half-lives estimated from 6-hour parasite counts. These results identify the measures that should be avoided and show that reliable clearance measures can be obtained with abbreviated monitoring protocols. © 2013 The Author 2013. .