Publication: Roles of D-amino acids on the bioactivity of host defense peptides
Issued Date
2016-07-01
Resource Type
ISSN
14220067
16616596
16616596
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2-s2.0-85016421372
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Molecular Sciences. Vol.17, No.7 (2016)
Suggested Citation
Hao Li, Nuttapat Anuwongcharoen, Aijaz Ahmad Malik, Virapong Prachayasittikul, Jarl E.S. Wikberg, Chanin Nantasenamat Roles of D-amino acids on the bioactivity of host defense peptides. International Journal of Molecular Sciences. Vol.17, No.7 (2016). doi:10.3390/ijms17071023 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/42926
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Title
Roles of D-amino acids on the bioactivity of host defense peptides
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Abstract
© 2016 by the authors; licensee MDPI, Basel, Switzerland. Host defense peptides (HDPs) are positively-charged and amphipathic components of the innate immune system that have demonstrated great potential to become the next generation of broad spectrum therapeutic agents effective against a vast array of pathogens and tumor. As such, many approaches have been taken to improve the therapeutic efficacy of HDPs. Amongst these methods, the incorporation of D-amino acids (D-AA) is an approach that has demonstrated consistent success in improving HDPs. Although, virtually all HDP review articles briefly mentioned about the role of D-AA, however it is rather surprising that no systematic review specifically dedicated to this topic exists. Given the impact that D-AA incorporation has on HDPs, this review aims to fill that void with a systematic discussion of the impact of D-AA on HDPs.