Publication: Association between bone mineral density and erythropoiesis in Thai children and adolescents with thalassemia syndromes
Issued Date
2006-03-01
Resource Type
ISSN
09148779
Other identifier(s)
2-s2.0-33646474176
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Bone and Mineral Metabolism. Vol.24, No.2 (2006), 146-152
Suggested Citation
Pat Mahachoklertwattana, Pensri Pootrakul, Ampaiwan Chuansumrit, Lulin Choubtum, Arporn Sriphrapradang, Rojana Sirisriro, Rajata Rajatanavin Association between bone mineral density and erythropoiesis in Thai children and adolescents with thalassemia syndromes. Journal of Bone and Mineral Metabolism. Vol.24, No.2 (2006), 146-152. doi:10.1007/s00774-005-0661-0 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23068
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Association between bone mineral density and erythropoiesis in Thai children and adolescents with thalassemia syndromes
Other Contributor(s)
Abstract
Increased marrow erythropoiesis in patients with thalassemia syndromes results in the expansion of bone marrow cavities and consequently decreases bone tissues, leading to osteoporosis. Whether the soluble transferrin receptor (sTfR), a marker of erythropoietic activity, correlates with the bone mineral density (BMD) in thalassemic patients has not previously been addressed. Forty-six children and adolescents with thalassemia syndromes, who were either not transfused or suboptimally transfused, were studied. BMD was determined by dual-energy X-ray absorptiometry. Blood samples were obtained in order to determine sTfR and hemoglobin. The patients were categorized into four groups: 1, β-thalassemia/hemoglobin E (β-thal/E) with transfusion-dependency (TD) (n = 18); 2, β-thal/E with transfusion-independency (TI) (n = 15); 3, β-thalassemia major (β-major) (n = 6); 4, hemoglobin H (HbH) (n = 7). All patients had normal serum free thyroxine (FT4) and thyroid-stimulating hormone (TSH), and intact parathyroid hormone (PTH), serum calcium (Ca), phosphate (P), and 25-OH-vitamin D levels. The BMD of patients in the β-major and β-thal/E with TD groups were not significantly different. In comparison with the β-major and β-thal/E with TD groups, the β-thal/E with TI and HbH groups had significantly higher BMD of the total body (TB), femoral neck (FN), and lumbar spine (LS), as well as higher levels of hemoglobin. In contrast, the sTfR levels of the β-major, β-thal/E with TI, and HbH groups were significantly lower than those of the β-thal/E with TD group. The BMD of TB, FN, and LS was negatively correlated with the sTfR level, but positively correlated with the hemoglobin level. In conclusion, increased marrow erythropoiesis is one of the major determinants of reduced bone mass in thalassemic patients with either no transfusion or suboptimal transfusion. © Springer-Verlag 2006.