Publication: Opsonophagocytosis and intracellular killing activity of neutrophils in patients with human immunodeficiency virus infection
Issued Date
1996-06-01
Resource Type
ISSN
0125877X
Other identifier(s)
2-s2.0-0030419447
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asian Pacific Journal of Allergy and Immunology. Vol.14, No.1 (1996), 49-56
Suggested Citation
Kalaya Tachavanich, Kovit Pattanapanyasat, Suttipant Sarasombath, Surapol Suwannagool, Vinai Suvattee Opsonophagocytosis and intracellular killing activity of neutrophils in patients with human immunodeficiency virus infection. Asian Pacific Journal of Allergy and Immunology. Vol.14, No.1 (1996), 49-56. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17618
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Title
Opsonophagocytosis and intracellular killing activity of neutrophils in patients with human immunodeficiency virus infection
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Abstract
In this study, neutrophils isolated from asymptomatic HIV positive individuals, patients with AIDS-related complex (ARC), ARC patients receiving zidovudine (AZT) and full-blown AIDS patients were assayed for their opsonophagocytic and intracellular killing activities. Progressively decreasing opsonophagocytosis of C. albicans by neutrophils correlated with increasing severity of the disease in all groups of HIV infected individuals, as compared to neutrophils isolated from healthy controls. The intracellular killing of C. albicans by neutrophils of asymptomatic and ARC patients did not differ significantly from controls. Neutrophils of ARC patients receiving AZT and AIDS patients showed a slightly decreased killing activity in comparison to that of neutrophils from healthy controls.