Publication: Primaquine-induced haemolysis in females heterozygous for G6PD deficiency
Issued Date
2018-03-02
Resource Type
ISSN
14752875
Other identifier(s)
2-s2.0-85042880666
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Malaria Journal. Vol.17, No.1 (2018)
Suggested Citation
Cindy S. Chu, Germana Bancone, François Nosten, Nicholas J. White, Lucio Luzzatto Primaquine-induced haemolysis in females heterozygous for G6PD deficiency. Malaria Journal. Vol.17, No.1 (2018). doi:10.1186/s12936-018-2248-y Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/46040
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Primaquine-induced haemolysis in females heterozygous for G6PD deficiency
Abstract
© 2018 The Author(s). Oxidative agents can cause acute haemolytic anaemia in persons with G6PD deficiency. Understanding the relationship between G6PD genotype and the phenotypic expression of the enzyme deficiency is necessary so that severe haemolysis can be avoided. The patterns of oxidative haemolysis have been well described in G6PD deficient hemizygous males and homozygous females; and haemolysis in the proportionally more numerous heterozygous females has been documented mainly following consumption of fava beans and more recently dapsone. It has long been known that 8-aminoquinolines, notably primaquine and tafenoquine, cause acute haemolysis in G6PD deficiency. To support wider use of primaquine in Plasmodium vivax elimination, more data are needed on the haemolytic consequences of 8-aminoquinolines in G6PD heterozygous females. Two recent studies (in 2017) have provided precisely such data; and the need has emerged for the development of point of care quantitative testing of G6PD activity. Another priority is exploring alternative 8-aminoquinoline dosing regimens that are practical and improve safety in G6PD deficient individuals.