Publication: Morinda citrifolia leaves enhance osteogenic differentiation and mineralization of human periodontal ligament cells
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Issued Date
2014-01-01
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ISSN
18811361
02874547
02874547
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2-s2.0-84897105002
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Mahidol University
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SCOPUS
Bibliographic Citation
Dental Materials Journal. Vol.33, No.2 (2014), 157-165
Suggested Citation
Kanitsak Boonanantanasarn, Kajohnkiart Janebodin, Prapan Suppakpatana, Tawepong Arayapisit, Jit Aree Rodsutthi, Panjit Chunhabundit, Surintorn Boonanuntanasarn, Wanida Sripairojthikoon Morinda citrifolia leaves enhance osteogenic differentiation and mineralization of human periodontal ligament cells. Dental Materials Journal. Vol.33, No.2 (2014), 157-165. doi:10.4012/dmj.2012-053-r Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/33786
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Title
Morinda citrifolia leaves enhance osteogenic differentiation and mineralization of human periodontal ligament cells
Abstract
This present study investigated the potential of Morinda citrifolia leaf aqueous extract to induce osteogenic differentiation and matrix mineralization of human periodontal ligament (hPDL) cells. Human periodontal ligament cells were cultured in complete medium, ascorbic acid with β-glycerophosphate, or Morinda citrifolia leaf aqueous extract. Morinda citrifolia leaf aqueous extract significantly increased alkaline phosphatase activity compared to culturing in complete medium or ascorbic acid with β-glycerophosphate. Matrixcontaining mineralized nodules were formed only when the cells were cultured in the presence of Morinda citrifolia leaf aqueous extract. These nodules showed positive alizarin red S staining and were rich in calcium and phosphorus according to energy dispersive X-ray analysis. In conclusion, Morinda citrifolia leaf extract promoted osteogenic differentiation and matrix mineralization in human periodontal ligament cells, a clear indication of the therapeutic potential of Morinda citrifolia leaves in bone and periodontal tissue regeneration.