Publication: Simple and selective method for determination of iodide in pharmaceutical products by flow injection analysis using the iodine-starch reaction
Issued Date
2004-02-01
Resource Type
ISSN
16182642
Other identifier(s)
2-s2.0-3042853217
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Mahidol University
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SCOPUS
Bibliographic Citation
Analytical and Bioanalytical Chemistry. Vol.378, No.3 (2004), 816-821
Suggested Citation
D. Nacapricha, K. Uraisin, N. Ratanawimarnwong, K. Grudpan Simple and selective method for determination of iodide in pharmaceutical products by flow injection analysis using the iodine-starch reaction. Analytical and Bioanalytical Chemistry. Vol.378, No.3 (2004), 816-821. doi:10.1007/s00216-003-2370-7 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/21230
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Title
Simple and selective method for determination of iodide in pharmaceutical products by flow injection analysis using the iodine-starch reaction
Author(s)
Abstract
This work exploited the well-known iodine-starch reaction for development of a simple flow-injection (FI) method for determination of iodide in pharmaceutical samples. Iodide in an injected zone was oxidized to iodine. A gas diffusion unit enables selective permeation of iodine through a hydrophobic membrane. Detection was made very selective for elemental iodine by employing formation of the I3--starch complex. The detection limit (3S/N) of the system was 1mgIL-1. For a liquid patent medicine used for asthma treatment we suggested modification of the system. Direct injection of this sample, which contains a particularly high concentration level of iodide (ca. 9000 mgIL-1), can be achieved by coupling a dialysis unit to the FI system. This has increased the working range to 6000-10,000 mgIL-1without employing complicated nanoliter injection. © Springer-Verlag 2003.
