Publication: Comparison of oseltamivir and oseltamivir carboxylate concentrations in venous plasma, venous blood, and capillary blood in healthy volunteers
Issued Date
2013-06-01
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10986596
00664804
00664804
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2-s2.0-84877867722
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Mahidol University
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SCOPUS
Bibliographic Citation
Antimicrobial Agents and Chemotherapy. Vol.57, No.6 (2013), 2858-2862
Suggested Citation
Insti Instiaty, Niklas Lindegardh, Podjanee Jittmal, Warunee Hanpithakpong, Daniel Blessborn, Sasithon Pukrittayakamee, Nicholas J. White, Joel Tarning Comparison of oseltamivir and oseltamivir carboxylate concentrations in venous plasma, venous blood, and capillary blood in healthy volunteers. Antimicrobial Agents and Chemotherapy. Vol.57, No.6 (2013), 2858-2862. doi:10.1128/AAC.02408-12 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/32320
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Title
Comparison of oseltamivir and oseltamivir carboxylate concentrations in venous plasma, venous blood, and capillary blood in healthy volunteers
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Abstract
Oseltamivir and oseltamivir carboxylate concentrations were measured in venous plasma, venous blood, and capillary blood taken simultaneously from 24 healthy volunteers. Median (range) venous-blood-to-plasma ratios were 1.42 (0.920 to 1.97) for oseltamivir and 0.673 (0.564 to 0.814) for oseltamivir carboxylate. Capillary blood/venous plasma ratios were 1.32 (0.737 to 3.16) for oseltamivir and 0.685 (0.502 to 1.34) for oseltamivir carboxylate. Oseltamivir concentrations in venous and capillary blood were similar. Oseltamivir carboxylate showed a time-dependent distribution between venous and capillary blood. Copyright © 2013, American Society for Microbiology. All Rights Reserved.