Arjen M. Dondorp, Piet A. Kager, Johan Vreeken, Nicholas J. White Abnormal blood flow and red blood cell deformability in severe malaria. Parasitology Today. Vol.16, No.6 (2000), 228-232. doi:10.1016/S0169-4758(00)01666-5 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/25983
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Abnormal blood flow and red blood cell deformability in severe malaria
Obstruction of the microcirculation plays a central role in the pathophysiology of severe malaria. Here, Arjen Dondorp and colleagues describe the various contributors to impaired microcirculatory flow in falciparum malaria: sequestration, rosetting and recent findings regarding impaired red blood cell deformability. The correlation with clinical findings and possible therapeutic consequences are discussed.
